Repeated sucrose access influences dopamine D2 receptor density in the striatum
Repeated sucrose access influences dopamine D2 receptor density in the striatum
复制标题
DOI：
10.1097/00001756-200208270-00017
复制
发表时间：
2002-08-27
期刊：
影响因子：
1.7
通讯作者：
Hajnal, A
中科院分区：
文献类型：
--
作者：
Bello, NT;Lucas, LR;Hajnal, A
据报道，在肥胖个体和药物成瘾者中，纹状体中的D2多巴胺受体亚型（D2R）结合减少。我们研究了D2R密度在纹状体的食物限制的大鼠，有偶然获得不同的激励值的食物。结果表明，动物接受有限的访问0.3 M蔗糖配对2小时与食物餐7天有一个显着较低的D2R结合在核壳和背外侧纹状体与动物相比，有有限的访问食物。然而，在任何一组中，都没有差异结合。这些研究结果表明，喂养条件和蔗糖摄入量的影响D2R密度，特别是在纹状体的子区域。
A decrease in D2 dopamine receptor subtype (D2R) binding in the striatum has been reported in obese individuals and drug addicts. We examined D2R density in the striatum of food-restricted rats that had contingent access to food with different incentive values. Results showed that animals receiving limited access to 0.3 M sucrose paired 2 h with a chow meal for 7 days had a significantly lower D2R binding in nucleus accumbens shell and dorsolateral striatum compared with animals that had limited access to chow. There was no differential binding, however, in the accumbens core in any of the groups. These findings indicate that feeding conditions and sucrose intake influence D2R density specifically in subregions of the striatum.