Immunohistochemical analysis of nm23 gene product/NDP kinase expression in pulmonary adenocarcinoma: lack of prognostic value.
Immunohistochemical analysis of nm23 gene product/NDP kinase expression in pulmonary adenocarcinoma: lack of prognostic value.
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DOI：
10.1038/bjc.1992.308
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发表时间：
1992-09
影响因子：
8.8
通讯作者：
Kimura, N
中科院分区：
文献类型：
--
作者：
Higashiyama, M;Doi, O;Yokouchi, H;Kodama, K;Nakamori, S;Tateishi, R;Kimura, N
nm 23基因产物/核苷二磷酸激酶（NDP激酶）的表达水平已被证明与几种肿瘤的转移潜力呈负相关，表明这可能是一个有用的工具作为预后指标。应用抗NDP激酶抗体，免疫组化法检测肺腺癌组织中nm 23基因产物/NDP激酶的表达水平。在88例受试患者中，39例（44%; B组）在肿瘤组织内的大多数癌细胞中显示出对NDP激酶的强免疫反应性，而49例（56%; A组）包含很少或没有NDP激酶阳性癌细胞。Nm 23基因产物/NDP激酶的表达与临床病理因素无关，出乎意料的是，两组之间的生存率没有相关性。因此，在肺腺癌中，nm 23基因产物/NDP激酶表达水平可能缺乏预后价值。
Levels of nm23 gene product/nucleoside diphosphate kinase (NDP kinase) expression have been demonstrated to correlate inversely with metastatic potential in several tumours, indicating that this could be a useful tool as a prognostic indicator. Using an antibody to NDP kinase, levels of nm23 gene product/NDP kinase expression in pulmonary adenocarcinoma were examined immunohistochemically. Of 88 patients tested, 39 (44%; Group B) showed strong immunoreactivity for NDP kinase in most of cancer cells within the tumour tissues, while 49 (56%; Group A) contained few or no NDP kinase-positive cancer cells. Nm23 gene product/NDP kinase was expressed independently of clinicopathological factors, and unexpectedly, no correlation of survival rates between both Groups could be demonstrated. Thus, in pulmonary adenocarcinoma, levels of nm23 gene product/NDP kinase expression may lack prognostic value.