Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology.
Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology.
复制标题
评估快速清除血池 MR 造影剂 (P792)，用于分析实验性乳腺肿瘤中与组织病理学相关的微血管特征。
DOI：
10.1002/mrm.1117
复制
发表时间：
2001
影响因子：
3.3
通讯作者：
Brasch,RC
中科院分区：
文献类型：
--
作者：
Turetschek,K;Floyd,E;Shames,DM;Roberts,TP;Preda,A;Novikov,V;Corot,C;Carter,WO;Brasch,RC
The diagnostic potential of a new rapid clearance blood pool contrast medium (P792; MW = 6.47 kDa) for the MR assessment of microvessel characteristics was assessed in 42 chemically‐induced breast tumors, with comparisons to albumin‐(Gd‐DTPA). Microvessel characteristics, including the transendothelial permeability (KPS) and the fractional blood volume (fPV), were estimated by using dynamic MR data fit to a bidirectional two‐compartment model. The MR‐derived estimates for KPSand fPV using each contrast agent were compared, and assays using each contrast agent were correlated to the histologic tumor grade (SBR score) and the microvascular density (MVD) counts. Using P792‐enhanced data, neither KPSnor fPV showed a statistically significant correlation with the tumor grade or the MVD (P> .05). Conversely, using albumin‐(GdDTPA)30, KPSvalues correlated significantly with the histologic tumor grade (r = .55;P< .0005) and the MVD (r = .34,P< .05), whereas no correlation was established for fPV. In conclusion, based on P792 data no correlation between tumor microvascular characteristics and histologic markers (SBR score or MVD) was found in this breast tumor model. Our analysis suggests that contrast media of relatively large (on the order of 90 kDa) molecular size, such as albumin‐(GdDTPA)30, are more accurate for the characterization of tumor microvessels. Magn Reson Med 45:880–886, 2001. © 2001 Wiley‐Liss, Inc.
