INTRACRANIAL COMPLIANCE IS TIME-DEPENDENT
INTRACRANIAL COMPLIANCE IS TIME-DEPENDENT
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DOI：
10.1227/00006123-198703000-00006
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发表时间：
1987-03-01
期刊：
影响因子：
4.8
通讯作者：
BRANCH, C
中科院分区：
文献类型：
--
作者：
ANILE, C;PORTNOY, HD;BRANCH, C
顺应性被认为是颅内系统的基本特征，可通过容积压试验（VPT）测量，并被认为与脑脊液（CSF）脉压（. delta . pcsf）有关。本研究旨在确定颅内依从性的时间依赖关系以及颅内脉压与依从性的关系。将9只狗分为两组，在不改变基线颅内压的情况下，通过打开或关闭颅骨来改变测试量的注射速度和颅内系统的物理顺应性。VPT采用三种方法：(a)慢速滴注。sbd.滴注0.3 ml，速度为1.5 ~ 0.2 ml/s; (b)快速滴注。sbd.滴注0.2 ml，速度为0.5 s; (c)快速滴注。sbd.滴注0.05 ml。颅骨闭合后，舒张期脑脊液压（Pcsf-d）与.DELTA.Pcsf呈线性关系；Pcsf-d与慢速输注、快速输注或大剂量注射；Pcsf-d和csf呼吸波振幅。颅骨打开后，仅Pcsf-d与. delta保持线性关系。Pcsf和Pcsf-d与大剂量注射。此外,.DELTA。无论颅骨打开还是关闭，Pcsf-d在任何水平上的振幅都是相同的。结论颅内顺应性可根据时间常数分为两部分，与。delta有关。生理顺应性，其时间常数较长，与VPT有关。
Compliance is considerd a fundamental characteristic of the intracranial system, is measured by the volume-pressure test (VPT), and is considerd to be related to the cerebrospinal fluid (CSF) pulse pressure (.DELTA.Pcsf). This study was carried out to determine the time-dependent relationship of intracranial compliance and the relationship between intracranial pulse pressure and compliance. In nine dogs divided into two groups, the rate of injection of a test volume and the physical compliance of the intracranial system was altered by opening or closing the skull without altering the baseline intracranial pressure. The VPT was carried out by three methods: (a) slow infusion.sbd.infusion of 0.3 ml at 1.5 to 0.2 ml/second, (b) fast infusion.sbd.infusion of 0.2 ml in 0.5 second, and (c) bolus injection.sbd.injection of 0.05 ml as rapidly as possible. With the skull closed, there were linear relationships between diastolic CSF pressure (Pcsf-d) and .DELTA.Pcsf; Pcsf-d and slow infusion, fast infusion, or bolus injection; and Pcsf-d and CSFrespiratory wave amplitude. With the skull open, the linear relationship was retained only for Pcsf-d vs. .DELTA.Pcsf and Pcsf-d vs. bolus injection. Furthermore, .DELTA.Pcsf amplitude at any level of Pcsf-d was the same whether the skull was open or closed. It is concluded that intracranial compliance can be divided into two components based on the time constant and is related to .DELTA.Pcsf, and physiological compliance, which has a longer time constant and is related to the VPT.