PDLIM1: Structure, function and implication in cancer.
PDLIM1: Structure, function and implication in cancer.
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PDLIM1：结构、功能及其在癌症中的意义
DOI：
10.15698/cst2021.08.254
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发表时间：
2021-08
期刊：
影响因子：
6.4
通讯作者：
Peng Y
中科院分区：
文献类型：
--
作者：
Zhou JK;Fan X;Cheng J;Liu W;Peng Y
PDLIM1是PDZ-LIM家族成员之一，是一种细胞骨架蛋白，作为形成不同蛋白复合物的平台，参与细胞骨架调节、突触形成等多种生理过程。越来越多的证据表明，PDLIM1在多种肿瘤中失调，并在肿瘤的发生和发展中发挥重要作用。本文就PDLIM1的结构、功能及其在人类癌症中的重要作用作一综述。
PDLIM1, a member of the PDZ-LIM family, is a cytoskeletal protein and functions as a platform to form distinct protein complexes, thus participating in multiple physiological processes such as cytoskeleton regulation and synapse formation. Emerging evidence demonstrates that PDLIM1 is dysregualted in a variety of tumors and plays essential roles in tumor initiation and progression. In this review, we summarize the structure and function of PDLIM1, as well as its important roles in human cancers.