Targeting pericytes for therapeutic approaches to neurological disorders.
Targeting pericytes for therapeutic approaches to neurological disorders.
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DOI：
10.1007/s00401-018-1893-0
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发表时间：
2018-10
影响因子：
12.7
通讯作者：
Attwell D
中科院分区：
文献类型：
--
作者：
Cheng J;Korte N;Nortley R;Sethi H;Tang Y;Attwell D
许多中枢神经系统疾病目前缺乏有效的治疗，并且通常与微血管功能的缺陷有关，包括无法将血液提供的能量与神经元计算所使用的能量相匹配，或者血脑屏障的破坏。周细胞是一种位于毛细血管上的研究不足的细胞类型，在调节多种微血管功能方面至关重要，例如血管生成，血脑屏障，毛细血管血流和免疫细胞进入大脑的运动。它们也形成了隔离CNS受损部分的“神经胶质”瘢痕的一部分，并且可能具有干细胞样性质。最近的研究表明，周细胞在神经系统疾病中起着至关重要的作用，因此是多种疾病的治疗靶点，所述疾病包括中风、创伤性脑损伤、偏头痛、癫痫、脊髓损伤、糖尿病、亨廷顿病、阿尔茨海默病、糖尿病、多发性硬化症、神经胶质瘤、放射性坏死和肌萎缩性侧索硬化症。在这里，我们报告了我们对周细胞生物学的理解的最新进展，并讨论了周细胞如何被靶向开发新的治疗方法来治疗神经系统疾病，通过增加血流量，保护血脑屏障功能，调节免疫细胞进入中枢神经系统，以及调节受损区域血管和周围胶质瘢痕的形成。
Many central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood–brain barrier. Pericytes, an under-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood–brain barrier, capillary blood flow and the movement of immune cells into the brain. They also form part of the “glial” scar isolating damaged parts of the CNS, and may have stem cell-like properties. Recent studies have suggested that pericytes play a crucial role in neurological diseases, and are thus a therapeutic target in disorders as diverse as stroke, traumatic brain injury, migraine, epilepsy, spinal cord injury, diabetes, Huntington’s disease, Alzheimer’s disease, diabetes, multiple sclerosis, glioma, radiation necrosis and amyotrophic lateral sclerosis. Here we report recent advances in our understanding of pericyte biology and discuss how pericytes could be targeted to develop novel therapeutic approaches to neurological disorders, by increasing blood flow, preserving blood–brain barrier function, regulating immune cell entry to the CNS, and modulating formation of blood vessels in, and the glial scar around, damaged regions.
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影响因子：
9.8
作者：
Cuervo H;Pereira B;Nadeem T;Lin M;Lee F;Kitajewski J;Lin CS
通讯作者：
Lin CS
影响因子：
4.8
作者：
Bondjers, Cecilia;He, Liqun;Betsholtz, Christer
通讯作者：
Betsholtz, Christer
DOI：
10.1023/a:1011965307612
发表时间：
2001-01-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
Bandopadhyay, R;Orte, C;Allt, G
通讯作者：
Allt, G
影响因子：
25
作者：
Damisah EC;Hill RA;Tong L;Murray KN;Grutzendler J
通讯作者：
Grutzendler J
影响因子：
64.8
作者：
Ben-Zvi, Ayal;Lacoste, Baptiste;Kur, Esther;Andreone, Benjamin J.;Mayshar, Yoav;Yan, Han;Gu, Chenghua
通讯作者：
Gu, Chenghua