Colletolides A and B, two new γ-butyrolactone derivatives from the endophytic fungus Colletotrichum gloeosporioides

Colletolides A and B, two new γ-butyrolactone derivatives from the endophytic fungus Colletotrichum gloeosporioides
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Colletolides A 和 B,两种新的 γ-丁内酯衍生物,来自内生真菌胶孢炭疽菌 (Colletotrichum gloeosporioides)

DOI:
10.1016/j.phytol.2019.08.004
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发表时间:
2019-10-01
影响因子:
1.7
通讯作者:
Ye, Yong-Hao
Ye, Yong-Hao
中科院分区:
生物学4区
文献类型:
--
作者:
Li, Yu;Wei, Wei;Ye, Yong-Hao

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从药用植物罗丹丹属(Illigera rhodantha Hance)内生真菌炭疽菌(Colletotrichum gloeosporioides B12)的培养物中分离到两个新的γ -丁内酯衍生物colletolides A和B(1和2),以及三个已知的化合物:甾酮(3)、3-亚甲基异吲哚醌(4)和吲哚-3-乙酰胺(5)。并用HR-ESI-MS、NMR和ECD对其结构进行了表征。化合物1和2对米黄单胞菌具有中等抑菌活性。oryzae X. oryzae pv。mic1均为128 μ g/mL。
Two new gamma-butyrolactone derivatives, colletolides A and B (1 and 2), together with three known compounds, sclerone (3), 3-methyleneisoindolinon (4) and indole-3-acetamide (5), were isolated from the culture of the endophytic fungus Colletotrichum gloeosporioides B12, which resides in the medicinal plant Illigera rhodantha Hance. Their structures were characterized by a combination of HR-ESI-MS, NMR and ECD spectra. Compounds 1 and 2 showed moderate antibacterial activity against Xanthomonas oryzae pv. oryzae, X. oryzae pv. oryzicola and Ralstonia solanacearum with the same MIC values of 128 mu g/mL.