Regional differentiation of the medial prefrontal cortex in regulating adaptive responses to acute emotional stress
Regional differentiation of the medial prefrontal cortex in regulating adaptive responses to acute emotional stress
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DOI：
10.1523/jneurosci.4297-06.2006
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发表时间：
2006-12-13
影响因子：
5.3
通讯作者：
Sawchenko, Paul E.
中科院分区：
文献类型：
--
作者：
Radley, Jason J.;Arias, Carlos M.;Sawchenko, Paul E.
内侧前额叶皮质（mPFC）是整合认知-情感信息和调节下丘脑-垂体-肾上腺（HPA）轴对情绪应激反应的重要神经基质。应激反应的mPFC调节部分地通过室旁下丘脑核（PVH）实现，其容纳自主（交感肾上腺）和神经内分泌（HPA）效应器机制。虽然证据的重量表明，mPFC对压力相关的PVH输出的影响是抑制性的，不一致的结果已经报道，这样的工作往往把这个皮层区域作为一个单一的结构。在这里，我们比较了病变的背侧与腹侧方面的mPFC，集中在前边缘和边缘下区，分别对急性束缚应激诱导激活PVH细胞群介导的自主神经和神经内分泌反应的影响。背侧mPFC的损伤增强了PVH神经分泌区的Fos和促肾上腺皮质激素释放因子（CRF）mRNA的表达。腹侧mPFC的消融降低了应激诱导的Fos蛋白和CRF mRNA在该室的表达，但增加了参与中枢自主控制的PVH区域的Fos诱导。重复的实验在大鼠轴承逆行示踪剂存款标记PVH自主预测证实，腹侧mPFC病变选择性地增加应激诱导的Fos的表达，在确定的前自主神经元。最后，HPA激活响应急性应激的激素指数增强后背侧mPFC病变和腹侧mPFC病变后衰减。这些结果表明，背侧和腹侧方面的mPFC差异调节神经内分泌和自主PVH的输出，以应对情绪压力。
The medial prefrontal cortex (mPFC) is an important neural substrate for integrating cognitive-affective information and regulating the hypothalamo-pituitary-adrenal (HPA) axis response to emotional stress. mPFCmodulation of stress responses is effected in part via the paraventricular hypothalamic nucleus (PVH), which houses both autonomic (sympathoadrenal) and neuroendocrine ( HPA) effector mechanisms. Although the weight of evidence suggests that mPFC influences on stress-related PVH outputs are inhibitory, discordant findings have been reported, and such work has tended to treat this cortical region as a unitary structure. Here we compared the effects of lesions of the dorsal versus ventral aspects of mPFC, centered in the prelimbic and infralimbic fields, respectively, on acute restraint stress-induced activation of PVH cell groups mediating autonomic and neuroendocrine responses. Lesions to the dorsal mPFC enhanced restraint-induced Fos and corticotropin-releasing factor (CRF) mRNA expression in the neurosecretory region of PVH. Ablation of the ventral mPFC decreased stress-induced Fos protein and CRF mRNA expression in this compartment but increased Fos induction in PVH regions involved in central autonomic control. Repetition of the experiments in rats bearing retrograde tracer deposits to label PVH autonomic projections confirmed that ventral mPFC lesions selectively increased stress-induced Fos expression in identified preautonomic neurons. Finally, hormonal indices of HPA activation in response to acute stress were augmented after dorsal mPFC lesions and attenuated after ventral mPFC lesions. These results suggest that dorsal and ventral aspects of the mPFC differentially regulate neuroendocrine and autonomic PVH outputs in response to emotional stress.