Mode of action of halothane on histamine-induced airway constriction in dogs with reactive airways.
Mode of action of halothane on histamine-induced airway constriction in dogs with reactive airways.
复制标题
氟烷对反应性气道狗组胺引起的气道收缩的作用方式。
DOI：
10.1097/00000542-198608000-00007
复制
发表时间：
1986
期刊：
影响因子：
8.8
通讯作者：
Hirshman,CA
中科院分区：
文献类型：
--
作者：
Shah,MV;Hirshman,CA
为了确定临床浓度的氟烷是否对气道平滑肌具有直接松弛作用，作者比较了6只未治疗和用阿托品气雾剂（10 mg X ml-1）预治疗的basenji-灰狗（BG）在对照状态（硫喷妥钠）和氟烷麻醉期间（1.0和1.5 MAC）对组胺的剂量-反应曲线。连续监测肺阻力（RL）和动态顺应性（Cdyn）。在硫喷妥钠、氟烷（1.0 MAC和1.5 MAC）和阿托品气雾剂给药后，基线气道张力无显著差异。在硫喷妥钠麻醉，组胺产生剂量相关的增加RL和减少Cdyn。氟烷和阿托品均能显著减弱组胺1 mg × ml ~（-1）引起的支气管收缩。氟烷（1.0 MAC和1.5 MAC）和阿托品气雾剂对组胺相关支气管收缩的拮抗程度无显著差异。此外，在4只犬中，与单独使用阿托品相比，在阿托品存在下氟烷麻醉没有提供额外的保护。由于氟烷提供的保护并不大于单独的阿托品预处理，并且在阿托品中加入氟烷未能增加保护，因此可以得出结论，迷走神经反射阻滞是氟烷负责组胺诱导的支气管收缩衰减的主要作用。
To determine if clinical concentrations of halothane have direct relaxant effects on airway smooth muscle, the authors compared dose-response curves to histamine in the control state (thiopental) and during halothane anesthesia (1.0 and 1.5 MAC), in six basenji-greyhound (BG) dogs untreated and pretreated with atropine aerosols (10 mg X ml-1). Pulmonary resistance (RL) and dynamic compliance (Cdyn) were continuously monitored. Baseline airway tone was not significantly different during thiopental, halothane (1.0 MAC and 1.5 MAC), and after atropine aerosol administration. During thiopental anesthesia, histamine produced dose-related increases in RL and decreases in Cdyn. Both halothane and atropine significantly attenuated the bronchoconstriction induced by histamine 1 mg X ml-1. There was no significant differences in the extent of antagonism of histamine-related bronchoconstriction between halothane (1.0 MAC and 1.5 MAC) and the atropine aerosol. Moreover, in four dogs halothane anesthesia in the presence of atropine offered no additional protection compared with atropine alone. Because the protection afforded by halothane was not greater than that of atropine pretreatment alone, and the addition of halothane to atropine failed to increase the protection, it is concluded that block of vagal reflexes was the major action of halothane responsible for the attenuation of histamine-induced bronchoconstriction.