MULTIVITAMIN FOLIC-ACID SUPPLEMENTATION IN EARLY-PREGNANCY REDUCES THE PREVALENCE OF NEURAL-TUBE DEFECTS
MULTIVITAMIN FOLIC-ACID SUPPLEMENTATION IN EARLY-PREGNANCY REDUCES THE PREVALENCE OF NEURAL-TUBE DEFECTS
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DOI：
10.1001/jama.262.20.2847
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发表时间：
1989-11-24
影响因子：
120.7
通讯作者：
WILLETT, W
中科院分区：
文献类型：
--
作者：
MILUNSKY, A;JICK, H;WILLETT, W
我们在23491名接受母体血清α检测的妇女中研究了综合维生素的摄入，特别是叶酸与神经管缺陷风险的关系。-妊娠16周左右进行胎蛋白筛查或羊膜穿刺术。在22,776例妊娠中获得了完整的问卷调查和随后的妊娠结局信息，其中49例以神经管缺陷结束。在受孕前后从未使用复合维生素或仅在受孕前使用复合维生素的妇女中，神经管缺陷的患病率为每1000人中有3.5人。妊娠前6周服用含叶酸复合维生素的妇女神经管缺陷的发生率明显较低，为0.0.0.9 / 1000（患病率为0.27；95%可信区间为0.12 - 0.59，与从未服用的妇女相比）。在怀孕前6周服用不含叶酸的复合维生素的妇女、在怀孕前6周服用不含叶酸的复合维生素的妇女以及在怀孕7周或更长时间后开始服用含叶酸的复合维生素的妇女，患病率与未服用的妇女相似，患病率比接近1.0。
We examined the relation of multivitamin intake in general, and folic acid in particular, to the risk of neural tube defects in a cohort of 23 491 women undergoing maternal serum .alpha.-fetoprotein screening or amniocentesis around 16 weeks of gestation. Complete questionnaires and subsequent pregnancy outcome information was obtained in 22,776 pregnancies, 49 of which ended in a neural tube defect. The prevalence of neural tube defect was 3.5 per 1000 among women who never used multivitamins before or after conception or who used multivitamins before conception only. The prevalence of neural tube defects for women who used folic acid-containing multivitamins during the first 6 weeks of pregnancy was substantially lower.sbd.0.9 per 1000 (prevalence ratio, 0.27; 95% confidence interval, 0.12 to 0.59 compared with never users). For women who used multivitamins without folic acid during the first 6 weeks of pregnancy and women who used multivitamins without folic acid during the first 6 weeks of pregnancy and women who used multivitamins containing folic acid beginning after 7 or more weeks of pregnancy, the prevalences were similar to that of the nonusers and the prevalence ratios were close to 1.0.