The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers.

The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers.
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Hedgehog通路在胃肠道肿瘤化疗耐药中的作用。

DOI:
10.3390/cells10082030
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发表时间:
2021-08-09
期刊:
影响因子:
6
通讯作者:
Xie J
Xie J
中科院分区:
生物学2区
文献类型:
--
作者:
Liang Y;Yang L;Xie J

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Hedgehog通路在胚胎发育和干细胞调节中发挥重要作用,在胃肠癌中被激活。化疗在癌症治疗中被广泛使用。然而,化疗耐药成为癌症治疗的一大障碍。本文就Hedgehog通路在胃肠道肿瘤耐药中的作用以及针对Hedgehog信号通路的新药物和新策略的研究进展作一综述。
The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle in cancer therapy. This review focuses on the recent advances in the hedgehog pathway’s roles in drug resistance of gastrointestinal cancers and the novel drugs and strategies targeting hedgehog signaling.
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