Dysfunction between dorsal caudate and salience network associated with impaired cognitive flexibility in obsessive-compulsive disorder: A resting-state fMRI study
Dysfunction between dorsal caudate and salience network associated with impaired cognitive flexibility in obsessive-compulsive disorder: A resting-state fMRI study
复制标题
DOI：
10.1016/j.nicl.2019.102004
复制
发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Kanba, Shigenobu
中科院分区：
文献类型：
--
作者：
Tomiyama, Hirofumi;Nakao, Tomohiro;Kanba, Shigenobu
背景：认知灵活性受损与强迫症（OCD）的遗传基础有关。最近的强迫症内表型研究表明认知控制网络中的神经效率低下以及认知控制网络的边缘网络的干扰。探索功能性大脑网络与认知灵活性受损之间的关系可能会提供有关强迫症神经生物学基础的新信息。 方法：我们获得了静息态功能磁共振成像 (rsfMRI) 扫描，并使用威斯康星卡片分类测试 (WCST) 测量了 37 名未接受药物治疗的强迫症患者和 40 名健康对照 (HC) 参与者的认知灵活性。我们使用基于种子的方法探索了 OCD 组和 HC 组在与杏仁核和背侧纹状体感兴趣区 (ROI) 认知灵活性受损相关的功能性大脑网络中的差异。 结果：OCD 组和 HC 组在背侧尾状核的静息态功能网络中发现了显着差异。从背侧尾状核到背侧前扣带皮层 (dACC) 和前岛叶 (AI) 的功能连接增加与强迫症组认知灵活性较差有关，但 HC 组认知灵活性较好。结论：这些结果提供证据表明，强迫症患者认知灵活性受损可能与从背侧尾状核 (DC) 到显着网络重要节点的大脑网络功能障碍有关。我们的结果通过显示 OCD 和 HC 在功能网络和认知灵活性方面本质上不同的关联，扩展了 OCD 的神经心理学模型。
Background: Impaired cognitive flexibility has been implicated in the genetic basis of obsessive-compulsive disorder (OCD). Recent endophenotype studies of OCD showed neural inefficiency in the cognitive control network and interference by the limbic network of the cognitive control network. Exploring the relationship between the functional brain network and impaired cognitive flexibility may provide novel information about the neurobiological basis of OCD.Methods: We obtained resting-state functional magnetic resonance imaging (rsfMRI) scans and measured the cognitive flexibility of 37 medication-free OCD patients and 40 healthy control (HC) participants using the Wisconsin Card Sorting Test (WCST). We explored the difference between OCD and HC groups in the functional brain network related to impaired cognitive flexibility from the amygdala and dorsal striatal regions of interest (ROIs) by using a seed-based approach.Results: Significant differences between the OCD and HC groups were identified in the resting state functional network from the dorsal caudate. Increased functional connectivity from the dorsal caudate to the dorsal anterior cingulate cortex (dACC) and anterior insula (AI) was associated with poorer cognitive flexibility in the OCD group, but better cognitive flexibility in the HC group.Conclusions: These results provide evidence that the impaired cognitive flexibility of OCD may be associated with dysfunctions of the brain network from the dorsal caudate (DC) to important nodes of the salience network. Our results extend the neuropsychological model of OCD by showing intrinsically different associations between OCD and HC in functional network and cognitive flexibility.