The genetic component of middle ear disease in the first 5 years of life
The genetic component of middle ear disease in the first 5 years of life
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DOI：
10.1001/archotol.130.3.273
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发表时间：
2004-03-01
影响因子：
--
通讯作者：
Ferrell, RE
中科院分区：
文献类型：
--
作者：
Casselbrant, ML;Mandel, EM;Ferrell, RE
目的：确定中耳积液（middle ear effusion，中耳积液）和急性中耳炎发作时间的遗传因素。设计：前瞻性双胞胎/三胞胎队列。设置：三级儿科医院的研究中心。参与者：共招募了168名健康的同性双胞胎和7名同性三胞胎，年龄为2个月。干预措施：在每月评估时，以及在上呼吸道感染或中耳疾病症状期间进行检查时，通过气动耳镜检查和鼓室导抗法对中耳状态进行纵向评估。结果：在获得合子型的140组中，114组随访至3岁，83组随访至5岁。出生后5年内患病时间比例的遗传力估计值为0.72（P
Objective: To determine the genetic component of time with middle ear effusion (MEE) and episodes of MEE and acute otitis media.Design: Prospective twin/triplet cohort.Setting: Research center at a tertiary pediatric hospital.Participants: A total of 168 healthy same-sex twin and 7 same-sex triplet sets were recruited by age 2 months.Interventions: Longitudinal assessment of middle ear status by pneumatic otoscopy and tympanometry at monthly evaluations, and at examinations during upper respiratory tract infections or symptoms of middle ear disease.Outcome Measures: Proportion of time with MEE and episodes of acute otitis media and MEE.Results: Of the 140 sets for which zygosity was obtained, 114 were followed up to age 3 years and 83 sets to age 5 years. The heritability estimate for proportion of time with MEE in the first 5 years of life was 0.72 (P