Transient selective brain cooling confers neurovascular and functional protection from acute to chronic stages of ischemia/reperfusion brain injury
Transient selective brain cooling confers neurovascular and functional protection from acute to chronic stages of ischemia/reperfusion brain injury
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瞬时选择性脑冷却可在缺血/再灌注脑损伤的急性至慢性阶段提供神经血管和功能保护
DOI：
10.1177/0271678x18808174
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Zhao J;Mu H;Liu L
明智地使用低温可以减轻缺血性损伤。然而，最佳治疗方案和中风后神经血管对低温干预反应的时间动力学尚未得到系统研究。这些差距减缓了低温作为抗中风疗法的临床转化。在这里，我们描述了短暂选择性脑低温（TSBH）对小鼠短暂性大脑中动脉闭塞引起的局灶性缺血/再灌注脑损伤的超急性至慢性阶段的影响。使用简单的冷却装置在脑缺血期间诱导 TSBH。这种治疗将死亡率从 31.8% 降低至 0%，并在受伤后至少 35 天内改善神经系统结果。 TSBH 减轻了超急性和急性损伤阶段（再灌注后 1-23 小时）的血脑屏障渗漏。这种血脑屏障的早期保护与小胶质细胞/巨噬细胞的抗炎表型极化、促炎细胞因子的产生减少以及亚急性损伤阶段（再灌注后三天）中性粒细胞和巨噬细胞的脑浸润减少有关。 TSBH 在受伤后至少 35 天内对灰质和白质产生持久的保护作用，并保留纤维束的长期电生理功能。总之，TSBH 可以改善实验性中风后神经血管单元从超急性到慢性损伤阶段的缺血/再灌注损伤。
Ischemic injury can be alleviated by the judicious use of hypothermia. However, the optimal regimens and the temporal kinetics of post-stroke neurovascular responses to hypothermic intervention have not been systematically studied. These gaps slow the clinical translation of hypothermia as an anti-stroke therapy. Here, we characterized the effects of transient selective brain hypothermia (TSBH) from the hyperacute to chronic stages of focal ischemia/reperfusion brain injury induced by transient middle cerebral artery occlusion in mice. A simple cooling device was used to induce TSBH during cerebral ischemia. This treatment reduced mortality from 31.8% to 0% and improved neurological outcomes for at least 35 days post-injury. TSBH mitigated blood–brain barrier leakage during the hyperacute and acute injury stages (1–23 h post-reperfusion). This early protection of the blood–brain barrier was associated with anti-inflammatory phenotypic polarization of microglia/macrophages, reduced production of pro-inflammatory cytokines, and less brain infiltration of neutrophils and macrophages during the subacute injury stage (three days post-reperfusion). TSBH elicited enduring protective effects on both grey and white matter for at least 35 days post-injury and preserved the long-term electrophysiological function of fiber tracts. In conclusion, TSBH ameliorates ischemia/reperfusion injury in the neurovascular unit from hyperacute to chronic injury stages after experimental stroke.
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10.1097/01.wcb.0000123904.17746.92
发表时间：
2004-08-01
影响因子：
6.3
作者：
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DOI：
10.1073/pnas.1621174114
发表时间：
2017-02-14
影响因子：
11.1
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