Multifunctional silica nanoparticles for optical and magnetic resonance imaging
Multifunctional silica nanoparticles for optical and magnetic resonance imaging
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DOI：
10.1515/hsz-2012-0251
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发表时间：
2013-01-01
影响因子：
3.7
通讯作者：
Engelmann, Joern
中科院分区：
文献类型：
--
作者：
Joshi, Rajendra;Feldmann, Verena;Engelmann, Joern
用钆 (Gd) 络合物、荧光团和细胞穿透肽对球形、无孔二氧化硅纳米颗粒 (SiO2-NPs) 的表面进行修饰，以在单个颗粒上实现多功能性。 Gd表面浓度为9-16μmol/g，导致纳米材料具有高局部纵向和横向弛豫率（分别类似于1x10(5)和5x10(5)/mm/s/NP）。体外观察到细胞快速摄取；然而，也形成了更大的细胞外团聚物。体内给药显示其在全身快速分布，24小时后除肺、肝和脾外的所有器官中荧光几乎完全消失。此类纳米粒子有潜力作为分子成像中有效的多模态探针。
The surface of spherical, nonporous silica nanoparticles (SiO2-NPs) was modified with gadolinium (Gd) complexes, fluorophores, and cell-penetrating peptides to achieve multifunctionality on a single particle. The Gd surface concentrations were 9-16 mu mol/g resulting in nanomaterials with high local longitudinal and transversal relaxivities (similar to 1x10(5) and similar to 5x10(5)/mm/s/NP, respectively). Rapid cellular uptake was observed in vitro; however, larger extracellular agglomerates were also formed. In vivo administration revealed a fast distribution throughout the body followed by a nearly complete disappearance of fluorescence in all organs except the lungs, liver, and spleen after 24 h. Such NPs have the potential to serve as efficient multimodal probes in molecular imaging.