Treadmill training in incomplete spinal cord injured rats
Treadmill training in incomplete spinal cord injured rats
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DOI：
10.1016/s0166-4328(00)00244-8
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发表时间：
2000-10-01
影响因子：
2.7
通讯作者：
Schwab, ME
中科院分区：
文献类型：
--
作者：
Fouad, K;Metz, GAS;Schwab, ME
跑步机训练已被证明可以加速脊椎猫的运动恢复并改善跑步机行走时的负重。在人类患者中，跑步机训练越来越多地用于不完全脊髓损伤后的康复。在这项研究中，我们检查了背部不完全损伤的脊髓损伤大鼠的训练效果。通过旷场运动评分、跑步机运动学分析和多项功能测试（即足迹评估、窄梁交叉、网格行走、旷场探索活动）来检查恢复情况。在受伤后 5 周的时间内，经过跑步机训练的大鼠以及未经训练的大鼠都出现了显着的恢复。与在损伤后 7-14 天表现出高水平自发后肢运动的对照损伤大鼠相比，在训练组中没有检测到为期 5 周的每日跑步机训练对运动结果的额外有益效果。观察到的唯一变化是受过训练的老鼠的探索活动稍大一些。很可能，幸存的腹侧和腹外侧纤维允许自发恢复和“自我训练”发生到系统跑步机训练无法提供额外改善的程度。 (C) 2000 Elsevier Science B.V. 保留所有权利。
Treadmill training has been shown to accelerate locomotor recovery and to improve weight bearing during treadmill walking in spinal cats. In human patients treadmill training is increasingly used in rehabilitation after incomplete spinal cord injury. In this study we examined training effects in spinal cord injured rats with an incomplete dorsal lesion. Recovery was examined with an open field locomotor score, kinematic analysis on the treadmill, and several functional tests (i.e. foot print evaluation, narrow beam crossing, grid walking, open field exploratory activity). During the course of 5 weeks after the injury, a substantial amount of recovery occurred in the treadmill trained as well as in the untrained rats. If compared to the control lesioned rats, which showed a high level of spontaneous hindlimb movements at 7-14 days post lesion, no additional beneficial effect of a 5-week daily treadmill training on the locomotor outcome could be detected in the trained group. The only change observed was a slightly larger exploratory activity of the trained rats. It is probable that the spared ventral and ventro-lateral fibers allowed spontaneous recovery and 'self-training' to occur to such an extend that systematic treadmill training did not provide additional improvement. (C) 2000 Elsevier Science B.V. All rights reserved.