A comparative study of transient flow rate steps and ramps for the efficient collection of kinetic data
A comparative study of transient flow rate steps and ramps for the efficient collection of kinetic data
复制标题
用于有效收集动力学数据的瞬态流速阶跃和斜坡的比较研究
DOI：
10.1039/d3re00696d
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发表时间：
2024
影响因子：
3.9
通讯作者：
Schrecker L
中科院分区：
文献类型：
--
作者：
Schrecker L
瞬态累积流速变化方法已被证明对于收集连续流反应的停留时间序列数据非常有效。在本研究中，将对从阶跃变化和线性流速斜坡收集的数据进行比较，以告知方法选择并最大限度地降低实施这些方法所需的自动化和控制的复杂性，而不影响数据的质量。使用两种不同的分析工具（在线 FTIR 和在线 HPLC），在两种不同的流动系统配置以及三个复杂性不断增加的化学反应中对方法进行了比较。这项工作发现，当以反向推出（从高到低流速）方式执行时，使用更简单的阶跃变化收集的数据质量与使用更复杂的斜坡方法收集的数据质量相当。
Transient cumulative flow rate varying methods have proven very effective for the collection of residence time series data for reactions in continuous flow. In this study, comparisons will be made between data collected from step changes and linear flow rate ramps, to inform method choice and minimise the complexity of automation and control needed to implement these methods, without compromising the quality of the data. Using two different analytical tools (in-line FTIR and on-line HPLC), the methods were compared in two different flow system configurations, and across three chemical reactions of increasing complexity. This work finds that the quality of the data collected using simpler step changes are comparable to that collected using more complex ramping methods, when performed in a reverse push-out (high to low flow rate) manner.