Disruptive Mood Dysregulation Disorder at Ages 13-18: Results from the National Comorbidity Survey-Adolescent Supplement
Disruptive Mood Dysregulation Disorder at Ages 13-18: Results from the National Comorbidity Survey-Adolescent Supplement
复制标题
DOI：
10.1089/cap.2015.0038
复制
发表时间：
2016-03-01
影响因子：
1.9
通讯作者：
Merikangas, Kathleen R.
中科院分区：
文献类型：
--
作者：
Althoff, Robert R.;Crehan, Eileen T.;Merikangas, Kathleen R.
目的：破坏性情绪失调障碍（DMDD）已被引入精神疾病诊断和统计手册，第5版，但这个新标签的效用和它所描述的儿童的临床相关性尚未确定。研究方法：DMDD诊断的替代指标是从科摩罗国家调查-青少年补充（NCS-A）6483名青少年（51.4%为女性）的数据中提取的，包括复合国际诊断访谈（CIDI）诊断和希恩残疾量表功能障碍的测量。交叉表和逻辑回归分析用于评估患病率和合并症。结果：在不考虑诊断层次和发作频率的情况下，共有310例（5.26%）青少年符合DMDD诊断标准。在患病率估计的低端，只有9名青少年（0.12%）符合最严格的代理诊断，他们也符合一些共病疾病和功能障碍的标准。青少年双相情感障碍的合并症和功能损害的发生率是相同的，无论他们是否符合DMDD的标准。结论：DMDD诊断涵盖了一小群患有多种其他精神和神经疾病的青少年。因此，至少在青少年中，这种诊断标签的特异性仍然是一个悬而未决的问题。
Objective: Disruptive mood dysregulation disorder (DMDD) has been introduced into the Diagnostic and Statistical Manual of Mental Disorders, 5th ed. but the utility of this new label and the clinical correlates of the children it describes are yet to be determined. Methods: A proxy for the DMDD diagnosis was extracted from the National Comorbidity Survey - Adolescent Supplement (NCS-A) data on 6483 adolescents (51.4% female) including Composite International Diagnostic Interview (CIDI) diagnoses and measures of impaired functioning from the Sheehan Disability Scale. Cross tabulations and logistic regression were used to assess for prevalence and comorbidity. Results: A total of 310 (5.26%) adolescents met the criteria for DMDD when diagnostic hierarchy and frequency of outbursts were not considered. At the low end of prevalence estimation, only nine adolescents (0.12%) met the most stringent proxy diagnosis, and they also met criteria for a number of comorbid disorders and functional impairment. The rates of comorbidity and functional impairment in adolescents with bipolar disorder were the same, irrespective of their meeting criteria for DMDD. Conclusions: The DMDD diagnosis captures a small group of adolescents with multiple other psychiatric and neurologic conditions. The specificity of this diagnostic label, therefore, at least in adolescents, remains an open question.