INCREASED INSULIN-SECRETION IN PUBERTY - A COMPENSATORY RESPONSE TO REDUCTIONS IN INSULIN SENSITIVITY
INCREASED INSULIN-SECRETION IN PUBERTY - A COMPENSATORY RESPONSE TO REDUCTIONS IN INSULIN SENSITIVITY
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DOI：
10.1016/s0022-3476(89)80438-x
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发表时间：
1989-06-01
影响因子：
5.1
通讯作者：
TAMBORLANE, WV
中科院分区：
文献类型：
--
作者：
CAPRIO, S;PLEWE, G;TAMBORLANE, WV
最近的研究表明，在正常儿童的青春期，胰岛素的作用会减少。为了确定这种抵抗是否会导致胰岛素分泌过多，我们在9名青春期前儿童和14名青春期健康儿童以及14名正常成年人中使用高血糖钳技术产生标准的高血糖刺激（高于禁食水平125 mg/dl 120分钟）。青少年空腹血浆胰岛素和c肽浓度高于青春期前和成人（p . p . toreq）。0.02)。尽管在葡萄糖钳夹过程中葡萄糖增量相同，青少年的第一阶段和第二阶段血浆胰岛素和c肽反应也明显高于青春期前或成人（p < 0.01）。尽管青少年胰岛素反应急剧增加，但维持高血糖所需的外源性葡萄糖量在三组中是相似的。儿童胰岛素反应与空腹血浆胰岛素样生长因子I水平直接相关（r = 0.60 ~ 0.70, p < 0.01）。我们得出结论，葡萄糖刺激的胰岛素分泌通常在青春期增加，这种反应可能补偿青春期诱导的胰岛素敏感性缺陷。
Recent studies have suggested that insulin action is reduced during puberty in normal children. To determine whether such resistance leads to excessive insulin secretion, we used the hyperglycemic clamp techniques to produce a standard hyperglycemic stimulus (125 mg/dl above fasting levels for 120 minutes) in 9 preadolescent and 14 adolescent healthy children and in 14 normal adults. Fasting plasma insulin and C-peptide concentrations were higher in adolescents than in preadolescents and adults (p .ltoreq. 0.02). Despite identical glucose increments during the glucose clamp procedure, both first- and second-phase plasma insulin and C-peptide responses were also markedly greater in adolescents than in preadolescents or adults (p < 0.01 vs. other groups). Despite sharply increased insulin responses in adolescents, the amount of exogenous glucose required to maintain hyperglycemia was similar in all three groups. Insulin responses in the children were directly correlated with fasting plasma levels of insulin-like growth factor I (r = 0.60 to 0.70, p < 0.01). We conclude that glucose-stimulated insulin secretion is normally increased during puberty, a response that may compensate for puberty induced defects in insulin sensitivity.