Leukocytes in Mammary Development and Cancer
Leukocytes in Mammary Development and Cancer
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DOI：
10.1101/cshperspect.a003285
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发表时间：
2011-03-01
影响因子：
7.2
通讯作者：
Pollard, Jeffrey W.
中科院分区：
文献类型：
--
作者：
Coussens, Lisa M.;Pollard, Jeffrey W.
先天性和适应性谱系的白细胞都是所有组织的正常细胞成分。这些重要的细胞不仅对调节正常组织内稳态至关重要，而且是所有生理和病理组织修复过程的重要旁分泌调节因子。本文总结了关于白细胞在乳腺发育的各个阶段以及癌症发展过程中的营养作用的最新见解，重点关注鼠科动物和人类。
Leukocytes, of both the innate and adaptive lineages, are normal cellular components of all tissues. These important cells not only are critical for regulating normal tissue homeostasis, but also are significant paracrine regulators of all physiologic and pathologic tissue repair processes. This article summarizes recent insights regarding the trophic roles of leukocytes at each stage of mammary gland development and during cancer development, with a focus on Murids and humans.