Age at Separation of Twin Pairs in the FinnTwin12 Study.
Age at Separation of Twin Pairs in the FinnTwin12 Study.
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FinnTwin12 研究中双胞胎分离时的年龄。
DOI：
10.1017/thg.2022.17
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Kaprio,Jaakko
中科院分区：
文献类型：
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作者：
Wang,Zhiyang;Whipp,Alyce;Heinonen-Guzejev,Marja;Kaprio,Jaakko
生活在同一个家庭使家庭成员暴露在共同的环境中，这可能反映在双胞胎分析的共同环境估计数中。双胞胎中同卵双生子分离的年龄标志着这种共同接触的结束，分离的年龄通常是研究中自我报告的。该研究的目的是总结从居住记录中分离的年龄，并使用它来验证FinnTwin12队列中第三和第四波数据收集时自我报告的分离状态和年龄。离职年龄是从地址信息中得出的，从出生起就与芬兰人口信息系统相关联。按性别和接合性列出了描述性统计。从居住记录中分离的平均年龄为20.36岁。女性比男性早分离，双卵对比单卵对早分离。我们还计算了第3和第4波自我报告的分离状态的敏感性和特异性，以及第4波自我报告的分离年龄的评分者间可靠性。从居住记录中分离的年龄与自我报告的一致性相对较差。这项工作使我们能够在未来的双胞胎研究中使用更精确和客观的测量共享环境。
Living in the same household exposes family members to shared environments and may be reflected in estimates of shared environment in twin analyses. The age at the separation of cotwins in a twin pair marks the end of such shared exposure, and the age of separation is commonly self-reported in studies. The objective of the study was to summarize the age at separation from residential records and use it to validate with self-reported separation status and age at the third and fourth wave of data collection in the FinnTwin12 cohort. Age at separation was generated from the address information, linking it to the Finnish Population information system since birth. Descriptive statistics by sex and zygosity are presented. The mean age at separation from residential records was 20.36 years old. Women separated earlier than men and dizygotic pairs earlier than monozygotic pairs. We also calculated the sensitivity and specificity with the self-reported separation status at waves 3 and 4, and interrater reliability with the self-reported separation age at wave 4. Age at separation from residential records had a relatively poor agreement with the self-report. This work enables us to use a more precise and objective measure for the shared environment in future twin studies.