Hyperactivated motility in sperm
Hyperactivated motility in sperm
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DOI：
10.1046/j.1439-0531.2003.00397.x
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发表时间：
2003-04-01
影响因子：
1.7
通讯作者：
Ho, HC
中科院分区：
文献类型：
--
作者：
Suarez, SS;Ho, HC
超活化是哺乳动物精子在受精部位和受精时间的运动模式。它可能对受精的成功至关重要，因为它增强了精子从输卵管壁分离的能力，在输卵管的输卵管腔中移动，穿透粘液物质，最后穿透卵母细胞的透明膜。超活化精子的运动在不同的物理条件下和不同的物种中出现不同，但基本上它涉及鞭毛弯曲幅度的增加，并且通常是节拍不对称。据推测，输卵管中存在一个或多个信号，在适当的时间启动过度激活;然而，还没有确定的。虽然调节超活化的信号转导级联仍有待完全描述，但很明显，钙离子与鞭毛的轴丝相互作用以开启超活化。虽然超活化经常发生在获能过程中，但这两个事件受不同途径的调节。
Hyperactivation is a movement pattern seen in sperm at the site and time of fertilization in mammals. It may be critical to the success of fertilization, because it enhances the ability of sperm to detach from the wall of the oviduct, to move around in the labyrinthine lumen of the oviduct, to penetrate mucous substances and, finally, to penetrate the zona pellucida of the oocyte. The movement of hyperactivated sperm appears different under different physical conditions and in different species, but basically it involves an increase in flagellar bend amplitude and, usually, beat asymmetry. Presumably, a signal or signals exist in the oviduct to initiate hyperactivation at the appropriate time; however, none has yet been identified with certainty. While the signal transduction cascade regulating hyperactivation remains to be completely described, it is clear that calcium ions interact with the axoneme of the flagellum to switch on hyperactivation. Although hyperactivation often occurs during the process of capacitation, the two events are regulated by somewhat different pathways.