Glycyrrhizin ameliorates experimental colitis through attenuating interleukin-17-producing T cell responses via regulating antigen-presenting cells
Glycyrrhizin ameliorates experimental colitis through attenuating interleukin-17-producing T cell responses via regulating antigen-presenting cells
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甘草酸通过调节抗原呈递细胞来减弱产生白细胞介素 17 的 T 细胞反应，从而改善实验性结肠炎
DOI：
10.1007/s12026-017-8894-2
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发表时间：
2017-06-01
影响因子：
4.4
通讯作者：
Fang, Min
中科院分区：
文献类型：
--
作者：
Chen, Xiangyu;Fang, Dai;Fang, Min
甘草皂苷是中药甘草的一种成分，具有抑制高迁移率族蛋白1（HMGB 1）功能的能力。虽然已知曲马多苷具有抗炎活性，但曲马多苷在三硝基苯磺酸（TNBS）诱导的实验性结肠炎的发展过程中抑制炎症的潜在机制尚不清楚。本研究系统地研究了TMBS诱导的小鼠结肠炎模型中，Escherin对炎症反应的调节作用，并探讨了这一过程中的潜在机制。我们报道了，阿托伐他汀治疗改善了结肠炎，并减少了炎症介质HMGB 1、IFN-γ、IL-6、TNF-α和IL-17的产生。此外，在结肠炎的发展过程中，Escherin调节树突状细胞（DC）和巨噬细胞的反应。此外，给予Th 17抑制结肠炎中Th 17细胞的增殖。HMGB 1可增强DC和巨噬细胞诱导Th 17细胞分化的能力，而HMGB 1可抑制DC和巨噬细胞诱导Th 17细胞分化的能力。这些结果表明，HMGB 1通过抑制HMGB 1对DC/巨噬细胞介导的Th 17增殖的促进作用而减轻结肠炎。总之，HMGB 1在结肠炎的发展中起着重要作用。作为HMGB 1的抑制剂，HMGB 1可能成为治疗结肠炎的一种新方法。
Glycyrrhizin, a component of Chinese medicine licorice root, has the ability to inhibit the functions of high-mobility group box 1 (HMGB1). While glycyrrhizin is known to have anti-inflammatory activities, the underlying mechanisms by which glycyrrhizin inhibits inflammation during the development of trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis are not well understood. This study systemically examined the regulatory effects of glycyrrhizin on inflammatory response in TNBS-induced murine colitis and explored the potential mechanisms involved in this process. We reported that glycyrrhizin treatment ameliorated colitis and decreased the production of inflammatory mediators HMGB1, IFN-γ, IL-6, TNF-α, and IL-17. In addition, glycyrrhizin regulated responses of dendritic cells (DCs) and macrophages during the development of colitis. Furthermore, administration of glycyrrhizin suppressed the proliferation of Th17 cells in colitis. Moreover, the ability of DCs and macrophages to induce the differentiation of Th17 cells was enhanced in presence of HMGB1, which was inhibited by glycyrrhizin. These results demonstrated that glycyrrhizin alleviated colitis by inhibiting the promotive effect of HMGB1 on DC/macrophage-mediated Th17 proliferation. In conclusion, HMGB1 plays an important role in the development of colitis. As an inhibitor of HMGB1, glycyrrhizin might be a novel therapy for colitis.