Radiobiological significance of beamline dependent proton energy distributions in a spread-out Bragg peak
Radiobiological significance of beamline dependent proton energy distributions in a spread-out Bragg peak
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DOI：
10.1118/1.598977
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发表时间：
2000-05-01
期刊：
影响因子：
3.8
通讯作者：
Goitein, M
中科院分区：
文献类型：
--
作者：
Paganetti, H;Goitein, M
类似的目标剂量可以用不同的混合辐射场来实现，即，粒子能量分布，由一个实际的质子束和距离调制器产生。在粒子治疗中递送的剂量可以被描述为通量乘以总质量阻止本领对粒子能量分布的积分。采用蒙特卡罗模拟方法研究了质子束入射到距离调制器系统上的能量和能散对相对生物学效应的影响。使用不同的射束，调整射束输送的条件，使得相似的扩展布拉格峰（SOBP）剂量被输送到模拟水体模。我们使用轨道结构模型计算了三种不同细胞系失活的RBE。RBE取决于剂量沉积的细节和被照射组织的生物学特性。我们的计算表明，对于不同的光束条件，相应的差异，总质量阻止本领分布反映在差异的RBE。然而，这些差异仅在低剂量和/或光束设置差异较大的SOBP的极远边缘处显著。(C)2000年美国医学物理学家协会。[S0094-2405（00）04305-4]。
Similar target doses can be achieved with different mixed radiation fields, i.e., particle energy distributions, produced by a practical proton beam and a range modulator. The dose delivered in particle therapy can be described as the integral of fluence times the total mass stopping power over the particle energy distributions. We employed Monte Carlo simulations to explore the influence on the relative biological effectiveness (RBE) of the energy and the energy spread of the proton beam incident on a range modulator system. Using different beams, the conditions of beam delivery were adjusted so that similar spread out Bragg peak (SOBP) doses were delivered to a simulated water phantom. We calculated the RBE for inactivation of three different cell lines using the track structure model. The RBE depends on the details of the dose deposition and the biological characteristics of the irradiated tissue. Our calculations show that, for differing beam conditions, the corresponding differences in the total mass stopping power distributions are reflected in differences in the RBE. However, these differences are remarkable only at the very distal edge of the SOBP, for low doses, and/or fur large differences in beam setup. (C) 2000 American Association of Physicists in Medicine. [S0094-2405(00)04305-4].