Reduced sympathoneural responses to the cold pressor testin individuals with essential hypertension and in those genetically predisposed to hypertension - No support for the "pressor reactor" hypothesis of hypertension development
Reduced sympathoneural responses to the cold pressor testin individuals with essential hypertension and in those genetically predisposed to hypertension - No support for the "pressor reactor" hypothesis of hypertension development
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DOI：
10.1016/j.amjhyper.2004.05.008
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发表时间：
2004-10-01
影响因子：
3.2
通讯作者：
Schlaich, MP
中科院分区：
文献类型：
--
作者：
Lambert, EA;Schlaich, MP
背景：本研究旨在探讨高血压遗传易感性和年龄对交感神经系统冷压试验（CPT）反应的影响。方法：选取年龄27 +/- 2岁的32例年轻受试者，其中无高血压家族史（FH）的正常受试者11例，有强烈高血压家族史（FH+）的正常受试者14例，高血压患者8例。此外，还研究了21名年龄较大的受试者（53±2岁）：13名高血压患者和8名正常受试者。记录静息时和2分钟CPT期间的血压（BP）、心率（HR）和肌肉交感神经活动（MSNA）。结果：青年和老年高血压患者的静息MSNA均高于正常高血压患者（47 +/- 7 v 29 +/- 4次/ 100次心跳（P < 0.05）和66 +/- 4 v 40 +/- 7次/ 100次心跳（P < 0.01））。CPT导致各组患者心率增加的幅度相似。FH+组收缩压升高幅度略低于FH-组（P < 0.05）。FH-组的MSNA升高幅度（103%）远大于FH+组（32%）和青年高血压患者（12%）（P < 0.05）。同样，老年正常血压患者的MSNA随CPT的变化大于老年高血压患者（61% vs 12%, P < 0.05）。结论：我们的研究结果表明，在高血压患者和有高血压家族史的患者中，CPT诱导的交感神经反应是亚正常的，这突出了遗传因素在决定CPT交感神经反应性中的重要性。(C) 2004中国高血压杂志
Background: The aim of this study was to examine the influences of genetic predisposition to hypertension and of age on the sympathetic nervous system response to the cold pressor test (CPT).Methods: A total of 32 young subjects (aged 27 +/- 2 years) were studied: 11 normotensive subjects without a family history of hypertension (FH), 14 normotensive subjects with a strong family history of hypertension (FH+), and eight hypertensive subjects. In addition, 21 older subjects (aged 53 +/- 2 years) were studied: 13 hypertensive and eight normotensive subjects. Blood pressure (BP), heart rate (HR), and muscle sympathetic nerve activity (MSNA) were recorded at rest and during a 2-min period of a CPT.Results: Both young and older hypertensive subjects had higher resting MSNA than did the normotensive ones (47 +/- 7 v 29 +/- 4 bursts per 100 heartbeats (P < .05) and 66 +/- 4 v 40 +/- 7 bursts per 100 heartbeats (P < .01), respectively). The CPT resulted in HR increases of similar magnitude in all groups of patients. The FH+ group displayed slightly less increase in systolic BP than that of the FH- group (P < .05). The MSNA increased to a far greater degree in FH- (103%) than in FH+ (32%) and in young hypertensive patients (12%) (P < .05). Similarly, MSNA change with the CPT was greater in older normotensive subjects than in older hypertensive patients (61% v 12%, P < .05).Conclusions: Our results show that a CPT induces sympathetic responses that are subnormal in hypertensive patients and those with a family history of hypertension, highlighting the importance of genetic factors in determining the sympathetic nervous reactivity to CPT. (C) 2004 American Journal of Hypertension, Ltd.