Pathophysiological Study of Sensitive Skin
Pathophysiological Study of Sensitive Skin
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DOI：
10.2340/00015555-2235
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发表时间：
2016-01-01
影响因子：
3.6
通讯作者：
Misery, Laurent
中科院分区：
文献类型：
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作者：
Buhe, Virginie;Vie, Katell;Misery, Laurent
敏感性皮肤是一种临床综合征，其特征在于响应于各种因素（包括护肤产品、水、冷、热或其他物理和/或化学因素）而发生不愉快的感觉，例如瘙痒、烧灼或疼痛。虽然这些症状提示炎症和周围神经支配的激活，但敏感性皮肤的病理生理学仍然未知。我们系统地分析了50名健康女性的皮肤活检与非敏感或敏感的皮肤，并证明了表皮内神经纤维密度，特别是肽能C-纤维，是较低的敏感性皮肤组。这些纤维与疼痛、瘙痒和温度感知有关，它们的变性可能会促进异常性疼痛和类似症状。这些结果表明，皮肤敏感性的病理生理学类似于小纤维神经病变背景下的神经性瘙痒，环境因素可能会改变皮肤神经支配。
Sensitive skin is a clinical syndrome characterized by the occurrence of unpleasant sensations, such as pruritus, burning or pain, in response to various factors, including skincare products, water, cold, heat, or other physical and/or chemical factors. Although these symptoms suggest inflammation and the activation of peripheral innervation, the pathophysiogeny of sensitive skin remains unknown. We systematically analysed cutaneous biopsies from 50 healthy women with non-sensitive or sensitive skin and demonstrated that the intraepidermal nerve fibre density, especially that of peptidergic C-fibres, was lower in the sensitive skin group. These fibres are involved in pain, itching and temperature perception, and their degeneration may promote allodynia and similar symptoms. These results suggest that the pathophysiology of skin sensitivity resembles that of neuropathic pruritus within the context of small fibre neuropathy, and that environmental factors may alter skin innervation.