LOCALIZATION OF THE PROPERDIN FACTOR COMPLEMENT LOCUS PFC TO BAND-A3 ON THE MOUSE X-CHROMOSOME
LOCALIZATION OF THE PROPERDIN FACTOR COMPLEMENT LOCUS PFC TO BAND-A3 ON THE MOUSE X-CHROMOSOME
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DOI：
10.1017/s0016672300035230
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发表时间：
1990-10-01
影响因子：
1.5
通讯作者：
BOYD, Y
中科院分区：
文献类型：
--
作者：
EVANS, EP;BURTENSHAW, MD;BOYD, Y
备解素（备解素因子补体，Pfc）是一种血浆糖蛋白，通过与含有X;2罗伯逊易位的中期扩散进行原位杂交，已将其定位于小鼠X染色体的A3带。该基因座的X-连锁也已通过对小家鼠的分析得到证实。小家鼠种间杂交。Pfc的XA 3定位将其置于人和小鼠之间保守的染色体片段中，已知该染色体片段含有至少六个其他同源基因座（Cybb、Otc、Syn-1 Maoa、Araf、Timp）。
The locus for properdin (properdin factor complement, Pfc), a plasma glycoprotein, has been mapped to band A3 of the mouse X chromosome by in situ hybridization to metaphase spreads containing an X;2 Robertsonian translocation. The X-linkage of the locus has also been confirmed by analysis of Mus musculus .times. Mus spretus interspecific crosses. The XA3 localization for Pfc places it in the chromosomal segment conserved between man and mouse which is known to contain at least six other homologous loci (Cybb, Otc, Syn-1 Maoa, Araf, Timp).