Synthesizing cellular LOGIC

Synthesizing cellular LOGIC
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综合细胞逻辑

DOI:
10.1038/s41589-023-01280-y
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发表时间:
2023
影响因子:
14.8
通讯作者:
Wilson, Corey J.
Wilson, Corey J.
中科院分区:
生物学1区
文献类型:
--
作者:
Huang, Brian D.;De Pereda, Ana S.;Wilson, Corey J.

文献摘要

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工程合成工具,促进哺乳动物细胞的决策可以使无数的生物医学应用。研究人员现在已经开发出一种新的诱导物控制的转录因子系统,以促进基于模块化蛋白质融合级联的人类细胞中的合成决策(LOGIC)。
Engineering synthetic tools that facilitate decision-making in mammalian cells could enable myriad biomedical applications. Researchers have now developed a new system of inducer-controlled transcription factors to facilitate synthetic decision-making (LOGIC) in human cells based on modular protein-fusion cascades.