Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men
Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men
复制标题
DOI：
10.1016/j.amjhyper.2004.03.674
复制
发表时间：
2004-08-01
影响因子：
3.2
通讯作者：
Ueshima, H
中科院分区：
文献类型：
--
作者：
Mizushima, S;Ohshige, K;Ueshima, H
背景资料：采用随机双盲对照试验，研究了含两种三肽（缬氨酸-脯氨酸-脯氨酸和异亮氨酸-脯氨酸-脯氨酸）的酸奶对血压（BP）的影响。受试者被随机分为两组：酸奶饮料组（S组，n = 23）和安慰剂（酸化牛奶）饮料组（P组，n = 23），为期4周。在基线、第2周和第4周，由医生在公司的健康中心用水银血压计测量血压两次。结果：S组和P组基线收缩压（均数[SD]，S：147.6 [9.6]，P：145.3 [13.0]）和舒张压（S：95.3 [9.91]，P：91.5 [9.6]）均无显著性差异。在S组中，2周和4周时收缩压的变化分别为-4.3 mmHg（95%置信区间[CI] -8.3至-0.4; P = 0.032）和-5.2 mmHg（95% CI-10.1至-0.3; P = 0.039），均具有统计学显著性。舒张压分别在第2周和第4周从-1.7 mm Hg（95% CI-5.4至2.0）和-2.0（95% CI -5.4至1.5）变化。在P组中，收缩压变化为-0.5（95% CI-5.8至4.8），第2周和-3.7（95% CI-8.3至0.9），舒张压变化为-0.6（95%CI-4.7至3.6）和-0.3（95%CI-3.9至3.3）在4周，这是没有统计学意义的Conclusions：本试验证明了有益的影响，酸奶对血压的临界高血压男性谁不服用降压药物。(C)2004年美国高血压杂志有限公司
Background: A double-blind randomized controlled trial was carried out to assess the effect of sour milk, containing two tripeptides (valine-proline-proline and isoleucine-proline-proline), on blood pressure (BP).Methods: A total of 46 borderline hypertensive men aged 23 to 59 years were recruited at their workplace for this trial. Subjects were randomly allocated into two groups; sour milk drink group (S-group, n = 23) and placebo (acidified milk) drink group (P-group, n = 23) for 4 weeks. Blood pressure was measured twice at each occasion by a physician, at the health center of the company, with a mercury sphygmomanometer at baseline, 2 and 4 weeks. Statistical analysis was performed by SPSS 10.0J.Results: The S-group and P-group showed no significant difference in baseline systolic BP (mean [SD], S: 147.6 [9.6], P: 145.3 [13.0]) or diastolic BP (S: 95.3 [9.91, P: 91.5 [9.6]). In the S-group, change in systolic BP at 2 and 4 weeks were -4.3 mm Hg (95% confidence interval [CI] -8.3 to -0.4; P =.032) and -5.2 turn Hg (95% Cl -10.1 to -0.3; P =.039), both statistically significant. Diastolic BP showed change from -1.7 mm Hg (95% Cl -5.4 to 2.0) at 2 weeks and -2.0 (95% CI -5.4 to 1.5) at 4 weeks, respectively. In the P-group, change in systolic BP was -0.5 (95% Cl -5.8 to 4.8) at 2 weeks and -3.7 (95% Cl -8.3 to 0.9) at 4 weeks and change in diastolic BP was -0.6 (95% Cl -4.7 to 3.6) at 2 weeks and -0.3 (95% Cl -3.9 to 3.3) at 4 weeks, which were not statistically significant.Conclusions: This trial demonstrated the beneficial effect of sour milk on BP in borderline hypertensive men who were not taking antihypertensive medication. (C) 2004 American Journal of Hypertension, Ltd.