Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women
Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women
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DOI：
10.1155/2019/3295781
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发表时间：
2019-11-15
影响因子：
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通讯作者：
Wu, Ming
中科院分区：
文献类型：
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作者：
Chen, Fuxing;Zhu, Zheng;Wu, Ming
群体特异性组分（GC）基因是维生素D途径基因之一，在癌症的发展中似乎起着重要作用。一项基于人群的乳腺癌研究在中国人群中开展，包括818例病例和935例对照，以评估GC基因的四种多态性（rs16847024、rs17467825、rs2298850和rs3755967）与乳腺癌风险的潜在关联。在校正年龄、绝经状态、体重指数（BMI）、乳腺癌家族史、收入、腰围和教育程度后，我们发现三个snp对乳腺癌的发生有统计学意义的影响（rs17467825：校正OR = 0.80, 95% CI = 0.65-0.99； rs2298850：校正OR = 0.80, 95% CI = 0.65-0.98； rs3755967：校正OR = 0.80, 95% CI = 0.65-0.98）。分层分析发现，当一个人有腰围时
The group-specific component (GC) gene, one of the vitamin D pathway genes, seems to play an important role in cancer development. A population-based breast cancer study including 818 cases and 935 controls in a Chinese population was carried out to evaluate the potential associations of four polymorphisms (rs16847024, rs17467825, rs2298850, and rs3755967) in the GC gene with risk of breast cancer. We detected three SNPs with statistically significant effects on breast cancer development after adjusting for age, menopausal status, body mass index (BMI), family history of breast cancer, income, waist circumference, and education (rs17467825: adjusted OR = 0.80, 95% CI = 0.65-0.99; rs2298850: adjusted OR = 0.80, 95% CI = 0.65-0.98; rs3755967: adjusted OR = 0.80, 95% CI = 0.65-0.98). Stratified analysis found that when an individual had a waist circumference