Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein.
Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein.
复制标题
钙负反馈和RD3蛋白对视网膜膜鸟苷酸环化酶（RetGC）的调节
DOI：
10.1007/s00424-021-02523-4
复制
发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Peshenko IV
中科院分区：
文献类型：
--
作者：
Dizhoor AM;Peshenko IV
本文介绍了一个简要概述的主要生物化学和细胞过程中参与调节环GMP生产的光感受器。主要关注的是光感受器中游离钙浓度在光和暗之间的波动如何通过钙传感器蛋白调节视网膜膜鸟苷酸环化酶（RetGC）的活性。综述的重点是RetGC和鸟苷酸环化酶激活蛋白（GCAPs）的结构与其在光感受器和先天性光感受器疾病中的功能作用。除此之外，视网膜变性-3蛋白（RD 3）的结构和功能，以钙非依赖性的方式调节RetGC，详细讨论了其在光感受器生物学和遗传性视网膜失明中的作用。
This article presents a brief overview of the main biochemical and cellular processes involved in regulation of cyclic GMP production in photoreceptors. The main focus is on how the fluctuations of free calcium concentrations in photoreceptors between light and dark regulate the activity of retinal membrane guanylyl cyclase (RetGC) via calcium sensor proteins. The emphasis of the review is on the structure of RetGC and guanylyl cyclase activating proteins (GCAPs) in relation to their functional role in photoreceptors and congenital diseases of photoreceptors. In addition to that, the structure and function of retinal degeneration-3 protein (RD3), which regulates RetGC in a calcium-independent manner, is discussed in detail in connections with its role in photoreceptor biology and inherited retinal blindness.
影响因子：
4.8
作者：
Peshenko IV;Olshevskaya EV;Dizhoor AM
通讯作者：
Dizhoor AM