ANDROGEN RECEPTORS IN HEPATOCELLULAR-CARCINOMA AND SURROUNDING PARENCHYMA
ANDROGEN RECEPTORS IN HEPATOCELLULAR-CARCINOMA AND SURROUNDING PARENCHYMA
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DOI：
10.1016/0016-5085(85)90463-9
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发表时间：
1985-01-01
期刊：
影响因子：
29.4
通讯作者：
OGAWA, Y
中科院分区：
文献类型：
--
作者：
NAGASUE, N;ITO, A;OGAWA, Y
在慢性肝病患者中测定正常人肝、肝细胞癌和周围肝组织的雄激素受体含量。4男2女6例正常肝组织中均检测到雄激素受体。这6个个体中的雄激素受体含量范围为5.0-10.2 fmol/mg蛋白[Kd 10.6-31.8 × 10 - 6]。10-10 M]。2名慢性活动性肝炎患者和10名肝细胞癌患者的肝脏具有可检测量的雄激素受体，其范围为2.0 - 14.8 fmol/mg蛋白[Kd 4.0-30.9 × 10 - 6]。10-10 M]。在19例肝细胞癌患者中，14例胞浆中发现雄激素受体。滴度范围为3.7-45.4 fmol/mg蛋白[Kd 3.2-21.4 × 104]。10-10 M]。肝细胞癌雄激素受体浓度明显高于周围肝组织。在2名男性和1名女性中，雄激素受体在肝硬化中检测到，但在肿瘤中未检测到。在其余3名男性中，肿瘤和硬化性肝脏雄激素受体均为阴性。
The androgen receptor content of normal human liver, hepatocellular carcinoma, and surrounding liver tissue was determined in patients with chronic liver disease. Androgen receptor was detected in all 6 normal livers obtained from 4 men and 2 women. The androgen receptor content in these 6 individuals ranged from 5.0-10.2 fmol/mg protein [Kd 10.6-31.8 .times. 10-10 M]. The livers from 2 patients with chronic active hepatitis and from 10 cirrhotic patients with hepatocellular carcinoma had detectable amounts of androgen receptor ranging from 2.0 to 14.8 fmol/mg protein [Kd 4.0-30.9 .times. 10-10 M]. Androgen receptor was found in the cytosol of 14 of 19 men with hepatocellular carcinoma. The titer ranged from 3.7-45.4 fmol/mg protein [Kd 3.2-21.4 .times. 10-10 M]. Hepatocellular carcinoma had a significantly higher concentration of androgen receptor than did the surrounding cirrhotic liver tissue. In 2 men and 1 woman, androgen receptor was detected in the cirrhotic liver but not in the tumor. In the remaining 3 men, both tumor and cirrhotic liver were negative for androgen receptor.