Urinary neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for renal tubulointerstitial injury in IgA nephropathy
Urinary neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for renal tubulointerstitial injury in IgA nephropathy
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DOI：
10.1016/j.clim.2007.01.010
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发表时间：
2007-05-01
影响因子：
8.6
通讯作者：
Gao, Wenda
中科院分区：
文献类型：
--
作者：
Ding, Hanlu;He, Yani;Gao, Wenda
肾小管间质损伤在IgA肾病（IgAN）的发展中起重要作用，IgA肾病是肾小球肾炎最常见的形式。目前使用的生物标志物很少能灵敏地检测出肾小管损伤的早期迹象，这阻碍了我们及时推出预防和治疗措施。中性粒细胞明胶酶相关脂钙蛋白（NGAL）是一种急性期蛋白，在炎症和组织损伤时不仅从中性粒细胞中迅速释放，而且从多种细胞类型中迅速释放。其小分子大小和蛋白酶耐受性使其成为IgAN肾损伤的良好生物标志物。在这项研究中，我们通过测量40名健康个体和70名不同疾病严重程度的IgAN患者尿液中NGAL、肌酐和n -乙酰- β - d -氨基葡萄糖苷酶（NAG）的水平来验证这一假设。Lee III级IgAN患者尿NGAL水平和NGAL/肌酐值显著升高，与进行性肾小球系膜增生和小管间质损伤相关。与尿NAG水平相比，尿NGAL水平升高更为剧烈，即使在Lee 11级IgAN患者的NAG水平几乎没有变化的情况下，尿NGAL水平也可以很容易地检测到。我们的研究结果表明，尿液NGAL作为小管间质性疾病的早期生物标志物有很大的前景。IgA肾病和其他类型的肾脏疾病的损伤。(C) 2007爱思唯尔公司版权所有。
Renal tubulointerstitial injury plays an important role in the development of IgA nephropathy (IgAN), the most common form of glomerutonephritis. Few currently in use biomarkers can sensitively detect the earliest signs of renal tubular injury, hindering our efforts to launch preventive and therapeutic measures for this disorder in a timely manner. Neutrophil gelatinase-associated lipocalin (NGAL) is an acute phase protein that is rapidly released from not only neutrophils but also a variety of cell types upon inflammation and tissue injury. Its small molecular size and protease resistance could render it an excellent biomarker of renal injury in IgAN. In this study, we tested this hypothesis by measuring urinary levels of NGAL, creatinine and N-acetyl-beta-D-glucosaminidase (NAG) in 40 healthy individuals and 70 IgAN patients with various disease severities. The urinary NGAL levels and NGAL/creatinine values were significantly upregulated in Lee grade III IgAN patients, in correlation with progressive glomerular mesangial proliferation and tubutointerstitial injury. Compared with urinary NAG levels, the urinary NGAL levels elevated much more drastically and can be readily detected even in Lee grade 11 IgAN patients when their NAG levels showed almost no change. Our findings suggest the promising use of urinary NGAL as an early biomarker for tubulointerstitial. injury of IgA nephropathy and perhaps other types of renal disease in general. (C) 2007 Elsevier Inc. All rights reserved.