Determinants of cortisol awakening responses to naps and nighttime sleep
Determinants of cortisol awakening responses to naps and nighttime sleep
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DOI：
10.1016/j.psyneuen.2015.09.016
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发表时间：
2016-01-01
影响因子：
3.7
通讯作者：
Wolf, Jutta M.
中科院分区：
文献类型：
--
作者：
Devine, Jaime K.;Wolf, Jutta M.
皮质醇觉醒反应（CAR）是一种描述从睡眠中醒来后不久基础皮质醇水平急剧增加的现象。尽管进行了广泛的研究，但人们对睡眠结构对 CAR 的作用知之甚少。此外，短时间睡眠（小睡）后 CAR 的潜力尚未得到直接研究。因此，当前的研究旨在评估睡眠持续时间、一天中的时间和睡眠结构作为皮质醇觉醒反应的潜在决定因素。在几个脑电图监测的实验室睡眠条件后的第一个小时（0、30、45、60 分钟）内收集唾液样本。其中包括下午小睡，其中 17 名参与者（4 名男性；18-26 岁）小睡 50 分钟，24 名参与者（11 名男性；18-24 岁）小睡 90 分钟。此外，20 名参与者（10 名男性；年龄 18-35 岁）访问实验室两次，除了过夜外，还在安慰剂条件或药物控制睡眠条件（5 毫克唑吡坦）下早上小睡 90 分钟。除下午 50 分钟小睡外，每种睡眠条件下都观察到皮质醇增加。此外，夜间睡眠后的第 2 阶段睡眠（r=.46，p=.04）和安慰剂晨间小睡后的第 1 阶段睡眠（r=.54，p=.01）可以预测 CARS。当前的研究确定了小睡时皮质醇的觉醒反应，并暗示了小睡和夜间睡眠中 CAR 生成的睡眠持续时间和结构。因此，结合特定类型的睡眠来评估 CAR 可能有助于我们理解小睡对健康产生积极和消极影响的机制。 (C) 2015 Elsevier Ltd. 保留所有权利。
The cortisol awakening response (CAR) is a phenomenon describing the sharp increase in basal cortisol levels shortly after waking from sleep. While extensively studied, little is known about the role of sleep architecture contributing to CAR. Furthermore, the potential for CAR after a shorter bout of sleep - a nap - has not been directly investigated. The current studies thus aimed at assessed sleep duration, time of day, and sleep architecture as potential determinants of the cortisol awakening response.Saliva samples were collected during the first hour (0,30, 45, 60 min) following several EEG-monitored laboratory sleep conditions. Those included afternoon naps wherein 17 participants (4 men; ages 18-26) napped for 50 min and 24 participants (11 men; ages 18-24) napped for 90 min. Furthermore, 20 participants (10 men; ages 18-35) visited the lab twice and in addition to staying overnight, napped 90 min in the morning either under placebo conditions or pharmacologically-manipulated sleep conditions (5 mg Zolpidem).Cortisol increases were observed in response to each sleep condition except to 50-min afternoon naps. Furthermore, CARS were predicted by Stage 2 sleep when following nighttime sleep (r=.46, p=.04) and by Stage 1 sleep when following placebo morning naps (r=.54, p=.01).The current study established cortisol awakening responses to naps and implicates sleep duration and architecture in the generation of CAR to both napping and nighttime sleep. Assessing CAR in conjunction with the specific type of sleep may thus contribute to our understanding of mechanisms underlying positive and negative health effects of napping. (C) 2015 Elsevier Ltd. All rights reserved.