H9N2 influenza a viruses from poultry in Asia have human virus-like receptor specificity
H9N2 influenza a viruses from poultry in Asia have human virus-like receptor specificity
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DOI：
10.1006/viro.2000.0799
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发表时间：
2001-03-15
期刊：
影响因子：
3.7
通讯作者：
Webster, RG
中科院分区：
文献类型：
--
作者：
Matrosovich, MN;Krauss, S;Webster, RG
H9N2甲型流感病毒目前在亚洲的鸡、鹌鹑和其他家禽中广泛传播，并在人类中引起了一些流感病例。本研究发现，来自香港活禽市场的H9N2病毒具有与人类H3N2病毒相似的受体特异性。此外，家禽H9N2病毒的神经氨酸酶在吸血位点发生突变，这一特征与人类H2N2和H3N2病毒相似，但与其他禽类病毒不同。来自香港的H9N2病毒表面糖蛋白的特殊特征表明，该病毒更容易传入人类，并强调家禽在流感病毒人畜共患传播中的重要性。(C) 2001学术出版社。
H9N2 influenza A viruses are currently widespread in chickens, quail, and other poultry in Asia and have caused a few cases of influenza in humans. In this study, we found that H9N2 viruses from Hong Kong live bird markets have receptor specificity similar to that of human H3N2 viruses. In addition, the neuraminidase of poultry H9N2 viruses has mutations in its hemadsorbing site, a characteristic resembling that of human H2N2 and H3N2 viruses but differing from that of other avian viruses. Peculiar features of surface glycoproteins of H9N2 viruses from Hong Kong suggest an enhanced propensity for introduction into humans and emphasize the importance of poultry in the zoonotic transmission of influenza viruses. (C) 2001 Academic Press.