Association of diet with the onset of menopause in Japanese women
Association of diet with the onset of menopause in Japanese women
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DOI：
10.1093/aje/152.9.863
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发表时间：
2000-11-01
影响因子：
5
通讯作者：
Shimizu, H
中科院分区：
文献类型：
--
作者：
Nagata, C;Takatsuka, N;Shimizu, H
在日本岐阜的高山进行了一项前瞻性研究，以评估饮食与绝经发作之间的关系。研究人员通过邮件联系了1130名年龄在35-54岁的绝经前女性居民，她们于1992年完成了一份有效的半定量食物频率问卷，并于1998年进行了一份后续问卷，以更新绝经信息。绝经的开始被定义为女性在月经停止前12个月最后一次月经的年龄。在6年的研究期间，296名女性经历了自然更年期。在控制年龄、总能量、体重指数、吸烟年数和正常月经周期开始年龄后，使用Cox比例风险模型来估计绝经开始的风险比。作者发现，绿色蔬菜和黄色蔬菜的摄入量与6年的绝经发生率呈显著负相关（风险比= 0.71,95%可信区间：0.54，最高和最低四分位数的风险比为0.95，趋势p = 0.02）。胡萝卜素摄入量与绝经发生率的关联具有临界显著性（风险比= 0.78,95%可信区间：0.59,1.04，p为趋势值= 0.07）。
A prospective study was conducted in Takayama, Gifu, Japan, to evaluate the association between diet and the onset of menopause. A total of 1,130 female residents aged 35-54 years who were premenopausal and completed a validated semiquantitative food frequency questionnaire in 1992 were contacted by mail with a follow-up questionnaire in 1998 to update information on menopause. Onset of menopause was defined as a woman's age at the last menstrual period prior to stopping menstruation for 12 months. During the 6-year study period, 296 women experienced natural menopause. The Cox proportional hazards model was used to estimate hazard ratios of the onset of menopause after controlling for age, total energy, body mass index, years of smoking, and age at which regular menstrual cycle began. The authors found that green and yellow vegetable intake was significantly inversely associated with the 6-year incidence of menopause (hazard ratio = 0.71, 95% confidence interval: 0.54, 0.95 for the highest vs. lowest tertile of intake, p for trend = 0.02). Association of carotene intake with the incidence of menopause was of borderline significance (hazard ratio = 0.78, 95% confidence interval: 0.59, 1.04, p for trend = 0.07).