Subthalamic nucleus stimulation and levodopa-resistant postural instability in Parkinson's disease
Subthalamic nucleus stimulation and levodopa-resistant postural instability in Parkinson's disease
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DOI：
10.1007/s00415-008-0636-x
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发表时间：
2008-02-01
影响因子：
6
通讯作者：
Bloem, Bastiaan R.
中科院分区：
文献类型：
--
作者：
Visser, Jasper E.;Allum, John H. J.;Bloem, Bastiaan R.
We examined the effect of bilateral subthalamic nucleus stimulation on levodopa-resistant balance impairment in 14 patients with Parkinson's disease and 18 matched controls. Instability was quantitatively assessed using standardized multidirectional dynamic posturography. Patients were tested after taking a suprathreshold dose of levodopa, both with stimulators turned on and off. Patients with stimulators turned off were more unstable than controls following backward directed perturbations. Overall, patients' instability did not improve with STN stimulation, and considerable inter-individual variability was noted. Of note, marked levodopa-resistant axial motor symptoms before surgery correlated with an adverse treatment effect. We conclude that STN stimulation does not alleviate levodopa-resistant postural instability in Parkinson's disease.
