Biodegradable zinc-containing mesoporous silica nanoparticles for cancer therapy
Biodegradable zinc-containing mesoporous silica nanoparticles for cancer therapy
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DOI：
10.1016/j.mtadv.2020.100066
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发表时间：
2020-06-01
影响因子：
10
通讯作者：
Jones, J. R.
中科院分区：
文献类型：
--
作者：
Chen, S.;Greasley, S. L.;Jones, J. R.
三阴性乳腺癌极具侵袭性，治疗选择有限，因为癌细胞对激素治疗的反应降低。在这里，单分散含锌介孔二氧化硅纳米颗粒（MSNPs-Zn）被制成可调节的可生物降解平台，用于将治疗性锌离子输送到细胞中。我们证明纳米颗粒被细胞内化，并确定了一个治疗剂量窗口，其中msnp - zn对乳腺癌细胞有毒性，但对健康上皮细胞（MCF-10a）或小鼠巨噬细胞没有毒性。暴露于msnp - zn 24小时后，三阴性MDA-MB-231和MCF-7 （ER+）乳腺癌细胞的活力显著降低。更具侵袭性的MDA-MB-231细胞比MCF-7细胞对msnp - zn更敏感，具有更高的转移潜力。通过高分辨率透射电子显微镜成像，msnp - zn在细胞内进行生物降解，成为空心结构。介孔二氧化硅纳米颗粒为细胞内治疗性离子释放提供了可生物降解的载体。(C) 2020作者。Elsevier Ltd.出版。
Triple-negative breast cancers are extremely aggressive with limited treatment options because of the reduced response of the cancerous cells to hormonal therapy. Here, monodispersed zinc-containing mesoporous silica nanoparticles (MSNPs-Zn) were produced as a tuneable biodegradable platform for delivery of therapeutic zinc ions into cells. We demonstrate that the nanoparticles were internalized by cells, and a therapeutic dose window was identified in which the MSNPs-Zn were toxic to breast cancer cells but not to healthy epithelial (MCF-10a) cells or to murine macrophages. A significant reduction in the viability of triple negative MDA-MB-231 and MCF-7 (ER+) breast cancer cells was seen following 24 h exposure to MSNPs-Zn. The more aggressive MDA-MB-231 cells, with higher metastatic potential, were more sensitive to MSNPs-Zn than the MCF-7 cells. MSNPs-Zn underwent biodegradation inside the cells, becoming hollow structures, as imaged by high-resolution transmission electron microscopy. The mesoporous silica nanoparticles provide a biodegradable vehicle for therapeutic ion release inside cells. (C) 2020 The Author(s). Published by Elsevier Ltd.