Microtesla MRI of the human brain combined with MEG
Microtesla MRI of the human brain combined with MEG
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DOI：
10.1016/j.jmr.2008.06.007
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发表时间：
2008-09-01
影响因子：
2.2
通讯作者：
Kraus, Robert H., Jr.
中科院分区：
文献类型：
--
作者：
Zotev, Vadim S.;Matlashov, Andrei N.;Kraus, Robert H., Jr.
脑功能成像的挑战之一是互补成像模式的整合，如脑磁图（MEG）和功能磁共振成像（fMRI）。MEG使用高灵敏度超导量子干涉装置（SQUlDs）直接测量神经元电流的磁场，不能与传统的高场MRI在单一仪器中结合使用。MEG和MRI数据的间接匹配导致显著的共配准误差。最近提出的一种成像方法-基于squid的微特斯拉mri可以与MEG在同一系统中自然结合，直接提供MEG定位源的结构图。由于微特斯拉MR图像可以与高场MRI和其他技术提供的结构图像精确匹配，因此可以轻松准确地集成MEG和MRI/fMRI。在这里，我们报告了人类大脑的微特斯拉磁共振成像的第一张图像，连同听觉MEG（功能）数据，在相同的成像过程中使用相同的七通道SQUID系统记录。图像是在46 μ T测量下获得的，预极化为30 μ T。我们还估计了不同组织在微特斯拉场下的横向弛豫时间。我们的研究结果证明了微特斯拉核磁共振成像人脑成像的可行性和潜力。他们还表明，两种新型成像设备——用于在微特斯拉磁场下对人脑进行解剖核磁共振成像的低成本系统，以及用于综合功能（MEG）和结构（微特斯拉核磁共振成像）脑成像的更先进的设备——是实用的。Elsevier Inc.出版。
One of the challenges in functional brain imaging is integration of complementary imaging modalities, such as magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI). MEG, which uses highly sensitive superconducting quantum interference devices (SQUlDs) to directly measure magnetic fields of neuronal currents, cannot be combined with conventional high-field MRI in a single instrument. Indirect matching of MEG and MRI data leads to significant co-registration errors. A recently proposed imaging method-SQUID-based microtesla MRI-can be naturally combined with MEG in the same system to directly provide Structural maps for MEG-localized sources. It enables easy and accurate integration of MEG and MRI/fMRI, because microtesla MR images can be precisely matched to structural images provided by high-field MRI and other techniques. Here we report the first images of the human brain by microtesla MRI, together with auditory MEG (functional) data, recorded using the same seven-channel SQUID system during the same imaging session. The images were acquired at 46 mu T measurement Held with pre-polarization at 30 mT. We also estimated transverse relaxation times for different tissues at microtesla fields. Our results demonstrate feasibility and potential of human brain imaging by microtesla MRI. They also show that two new types of imaging equipment-low-cost systems for anatomical MRI of the human brain at microtesla fields, and more advanced instruments for combined functional (MEG) and structural (microtesla MRI) brain imaging-are practical. Published by Elsevier Inc.