Syntheses and some applications of chemically defined multivalent glycoconjugates
Syntheses and some applications of chemically defined multivalent glycoconjugates
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DOI：
10.1016/s0959-440x(96)80037-6
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发表时间：
1996-10-01
影响因子：
6.8
通讯作者：
Roy, R
中科院分区：
文献类型：
--
作者：
Roy, R
经典的多价新糖蛋白已被广泛用于研究大量的碳水化合物与蛋白质的相互作用。其他具有不同形状、价态和构象的新糖偶联物的合成已经达到相当复杂的水平，有望成为糖生物学和生物医学应用的新工具。在过去的几年里，在合成和了解水溶性糖共聚物的抗原性方面取得了进展。其中一些糖共聚物正被用作微生物粘附素的抑制剂和将药物输送到特定细胞的载体。新的树枝状碳水化合物结构正在成为碳水化合物结合蛋白的有效配体。
Classical multivalent neoglycoproteins have been widely used to study a great number of carbohydrate-protein interactions. The synthesis of other neoglycoconjugates with various shapes, valencies, and conformations has reached considerable levels of sophistication and holds promise as a new tool for glycobiology and biomedical applications. Within the last few years, advances have been made towards both the syntheses and understanding of the antigenic properties of water-soluble glycopolymers. Some of these glycopolymers are finding applications as inhibitors of microbial adhesins and as carriers for drug delivery to specific cells. Novel dendritic carbohydrate structures are emerging as potent ligands for carbohydrate-binding proteins.