Action observation has a positive impact on rehabilitation of motor deficits after stroke
Action observation has a positive impact on rehabilitation of motor deficits after stroke
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DOI：
10.1016/j.neuroimage.2007.03.043
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发表时间：
2007-01-01
期刊：
影响因子：
5.7
通讯作者：
Buccino, Giovanni
中科院分区：
文献类型：
--
作者：
Ertelt, Denis;Small, Steven;Buccino, Giovanni
有证据表明，对动作的观察激活了参与所观察到的动作的执行的相同皮层运动区。这一过程的神经基质是镜像神经元系统。我们利用这个神经系统和它的能力，重新制定存储的运动表征作为一种手段，康复motorcontrol.We相结合的日常行动的观察，伴随着物理训练观察到的行动，在一个新的神经康复计划（行动观察治疗）。八名中风患者中度，慢性运动功能障碍的上肢作为一个后果，内侧动脉梗死参加。在为期4周的治疗过程中，与稳定的治疗前基线相比，以及与对照组相比，运动功能有了显著改善。这种改善在干预结束后持续至少8周。此外，通过功能磁共振成像（fMRI）研究了动作观察疗法对运动系统重组的影响，使用由物体操作组成的独立感觉运动任务。训练后与训练前相同任务引起的神经激活的直接比较，在双侧腹侧运动前皮层、双侧颞上级回、辅助运动区（SMA）和对侧缘上回的活动显著增加。我们的研究结果提供的证据表明，行动观察有积极的额外影响恢复中风后的运动功能的运动区，其中包含的行动观察/行动执行匹配系统的重新激活。(C)2007年由Elsevier Inc.出版
Evidence exists that the observation of actions activates the same cortical motor areas that are involved in the performance of the observed actions. The neural substrate for this is the mirror neuron system. We harness this neuronal system and its ability to re-enact stored motor representations as a means for rehabilitating motor control.We combined observation of daily actions with concomitant physical training of the observed actions in a new neurorehabilitative program (action observation therapy). Eight stroke patients with moderate, chronic motor deficit of the upper limb as a consequence of medial artery infarction participated. A significant improvement of motor functions in the course of a 4-week treatment, as compared to the stable pre-treatment baseline, and compared with a control group have been found. The improvement lasted for at least 8 weeks after the end of the intervention.Additionally, the effects of action observation therapy on the reorganization of the motor system were investigated by functional magnetic resonance imaging (fMRI), using an independent sensorimotor task consisting of object manipulation. The direct comparison of neural activations between experimental and control groups after training with those elicited by the same task before training yielded a significant rise in activity in the bilateral ventral premotor cortex, bilateral superior temporal gyrus, the supplementary motor area (SMA) and the contralateral supramarginal gyros. Our results provide pieces of evidence that action observation has a positive additional impact on recovery of motor functions after stroke by reactivation of motor areas, which contain the action observation/ action execution matching system. (C) 2007 Published by Elsevier Inc.