Significance of the association between early embryonic development and endocytosis
Significance of the association between early embryonic development and endocytosis
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DOI：
10.1007/s00795-022-00331-y
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发表时间：
2022-07
影响因子：
1.8
通讯作者：
Akihito Morita;Yuhkoh Satouh;Ken Sato;Akira Iwase
中科院分区：
文献类型：
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作者：
Akihito Morita;Yuhkoh Satouh;Ken Sato;Akira Iwase
受精触发了一个被称为母体到合子转变的过程，其中卵母细胞经历卵母细胞到胚胎的转变，导致朝向早期胚胎发生的大量细胞内重塑。这种转变需要卵母细胞衍生成分的降解;然而，细胞表面成分降解的意义和机制仍然未知。本文就质膜蛋白的动态变化及其与胚胎发育和内吞作用的关系作一综述。我们对现有文献的调查得出的结论是，网格蛋白介导的内吞作用是必不可少的早期胚胎发育和卵母细胞衍生的质膜蛋白在小鼠胚胎中的选择性降解的进展，如研究分析母体细胞表面蛋白，包括甘氨酸转运蛋白，GlyT 1a。在单个胚胎中评估这种内吞活性可以允许在辅助生殖技术中选择具有更高生存力的胚胎，并且重要的是选择有活力的胚胎以增加成功怀孕和活产的比率。虽然早期胚胎发育异常主要伴有染色体非整倍体，但其他原因和机制尚不清楚。本文综述了早期胚胎发育异常的分子生物学研究进展及其前景。
Fertilization triggers a process called maternal-to-zygotic transition, in which the oocyte undergoes oocyte-to-embryo transition, leading to massive intracellular remodeling toward early embryogenesis. This transition requires the degradation of oocyte-derived components; however, the significance and mechanism of degradation of cell surface components remain unknown. In this review, we focused on the dynamics of plasma membrane proteins and investigated the relationship between embryonic development and endocytosis. Our survey of the extant literature on the topic led to the conclusion that clathrin-mediated endocytosis is essential for the progression of early embryogenesis and selective degradation of oocyte-derived plasma membrane proteins in mouse embryos, as reported by studies analyzing maternal cellular surface proteins, including a glycine transporter, GlyT1a. Evaluation of such endocytic activity in individual embryos may allow the selection of embryos with higher viability in assisted reproductive technologies, and it is important to select viable embryos to increase the rates of successful pregnancy and live birth. Although the early embryonic developmental abnormalities are mainly accompanied with chromosomal aneuploidy, other causes and mechanisms remain unclear. This review summarizes molecular biological approaches to early embryonic developmental abnormalities and their future prospects.