Alterations in the profile of blood cell types during malaria in previously unexposed primigravid monkeys.
Alterations in the profile of blood cell types during malaria in previously unexposed primigravid monkeys.
复制标题
先前未接触过疟疾的初孕猴中血细胞类型的变化。
DOI：
10.1086/430004
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Krogstad,DonaldJ
中科院分区：
文献类型：
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作者：
Davison,BillieB;Kaack,MBernice;Rogers,LindaB;Rasmussen,KelsiK;Rasmussen,Terri;Henson,ElizabethW;Montenegro,Sonia;Henson,MichaelC;Mzwaek,Fawaz;Krogstad,DonaldJ
Malaria in nonimmune, primigravid women threatens both mother and fetus. We used thePlasmodium coatneyi/rhesus monkey model to examine factors associated with this. Clinical and immunologic responses during the blood stage of chronic malaria (4 months) were evaluated in 8 malaria-naive primigravid (PMI) and 8 age-matched nulligravid (NMI) infected monkeys, compared with those in 8 primigravid, noninfected control monkeys. Although parasitemia levels were similar, recrudescence was more frequent and prolonged, and anemia was more severe in PMI than in NMI monkeys. During infection, CD2+, CD4+, and CD8+lymphocyte levels were higher in NMI than in PMI monkeys. Monocyte and neutrophil levels were lower in PMI than in NMI monkeys. During chronic, untreated malaria, NMI monkeys had a B lymphocyte count 23 times greater than that of PMI monkeys. Pregnancy-induced immunomodulation, defined as a lack of appropriate cellular responses to malaria, was indiscernible until the immune system was challenged by a pathogen
