Control communication and monitoring of intravaginal drug delivery in dairy cows
Control communication and monitoring of intravaginal drug delivery in dairy cows
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DOI：
10.1016/j.ijpharm.2004.05.023
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发表时间：
2004-09-10
影响因子：
5.8
通讯作者：
Rathbone, MJ
中科院分区：
文献类型：
--
作者：
Cross, PS;Künnemeyer, R;Rathbone, MJ
我们提出了一个电子控制药物输送系统的设计。位于阴道内的设备是一种低侵入性平台，可以在牛阴道内进行测量和反应，同时提供外部控制和监测能力。由现成组件制造的电子器件占据16 mL的TheratronTM注射器。微控制器读取和记录传感器数据并控制气室。产生的气体压力推动注射器活塞并释放制剂。双向无线电链路允许其它设备或基站之间的通信。原理证明实验证实了内部传感器合格的可变速率，任意轮廓药物输送。在7天内分配了30 mL的总体积，体积误差为+/-1 mL或更大体积的+/-7%。通过无线链路控制或覆盖交付，并检测和记录与其他设备的接近程度。结果表明，温度和活动传感或通过接近确定的社会群体可以用来检测发情和触发适当的反应。(C)2004 Elsevier B. V.保留所有权利。
We present the design of an electronically controlled drug delivery system. The intravaginally located device is a low-invasive platform that can measure and react inside the cow vagina while providing external control and monitoring ability. The electronics manufactured from off the shelf components occupies 16 mL of a Theratron(TM) syringe. A microcontroller reads and logs sensor data and controls a gascell. The generated gas pressure propels the syringe piston and releases the formulation. A two way radio link allows communication between other devices or a base station. Proof of principle experiments confirm variable-rate, arbitrary profile drug delivery qualified by internal sensors. A total volume of 30 mL was dispensed over a 7-day-period with a volume error of +/-1 mL or +/-7% for larger volumes. Delivery was controlled or overridden via the wireless link, and proximity to other devices was detected and recorded. The results suggest that temperature and activity sensing or social grouping determined via proximity can be used to detect oestrus and trigger appropriate responses. (C) 2004 Elsevier B.V. All rights reserved.