Lymphocyte Subsets and Inflammatory Mediators in Patients With Subacute Sclerosing Panencephalitis
Lymphocyte Subsets and Inflammatory Mediators in Patients With Subacute Sclerosing Panencephalitis
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亚急性硬化性全脑炎患者的淋巴细胞亚群和炎症介质
DOI：
10.1177/088307389901400702
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发表时间：
1999
影响因子：
1.9
通讯作者：
A. Huseyinov
中科院分区：
文献类型：
--
作者：
H. Tekgül;S. Tutuncuoglu;N. Kutukculer;G. Dizdarer;A. Huseyinov
亚急性硬化性全脑炎的发病机制可能与细胞免疫缺陷和炎性细胞因子有关。本研究分析了3例亚急性硬化性全脑炎患者免疫调节治疗（α-干扰素+异丙肌苷）前后外周血淋巴细胞亚群及血浆和脑脊液中白细胞介素-1 α（IL-1 α）、白细胞介素-2 α（IL-2 α）、肿瘤坏死因子-α（TNF-α）和血小板活化因子的浓度。治疗前CD8+细胞（T抑制细胞/细胞毒细胞）和CD16 + CD56+细胞（NK细胞）百分比升高，CD3 +/HLA-DR+（活性T细胞）和CD3+（总T细胞）百分比降低。经免疫调节治疗后，患者CD 3 +/HLA-DR+（活化T细胞）细胞明显升高，各淋巴细胞亚群百分比略有升高。血浆和脑脊液中血小板活化因子浓度高于对照组平均值。2例病程稳定的患者脑脊液和血浆TNF-α和IL-2水平未检出，3例病程快速进展的患者脑脊液和血浆TNF-α和IL-2水平显著升高。（J Child Neurol 1999; 14：418 - 421）。
A defective cell-mediated immunity and inflammatory cytokines are suggested in the pathogenesis of subacute sclerosing panencephalitis. In this study we analyzed lymphocyte subsets in peripheral blood and concentrations of interleukin-1α (IL-1α), interleukin-2 (IL-2α), tumor necrosis factor-α (TNF-α), and platelet activating factor in plasma and cerebrospinal fluid before and after immunomodulatory therapy (interferon-α plus isoprinosine) in three patients with subacute sclerosing panencephalitis. Increased percentage of CD8+cells (T-suppressor/cytotoxic cell) and CD16+CD56+cells (NK cell) and reduced percentage of CD3+/HLA-DR+ (active T-cell) and CD3+ (total T-cell) cells were found before therapy. After immunomodulatory therapy, CD3+/HLA-DR+ (active T-cell) cells were markedly increased and there was a slight increase in the percentages of all lymphocyte subsets in the patients. The concentrations of platelet activating factor in plasma and cerebrospinal fluid were higher than the mean value in controls. Cerebrospinal fluid and plasma TNF-α and IL-2 levels were nondetectable in two patients who had a stationary course of disease and were markedly elevated in patient 3, who displayed a rapidly progressive course. (J Child Neurol 1999;14:418-421).