Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults
Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults
复制标题
DOI：
10.1056/nejm199806043382302
复制
发表时间：
1998-06-04
影响因子：
158.5
通讯作者：
Wattigney, WA
中科院分区：
文献类型：
--
作者：
Berenson, GS;Srinivasan, SR;Wattigney, WA
背景：在成年人中，心血管危险因素对心血管事件的影响是相互促进的。然而，关于多种危险因素与年轻人无症状动脉粥样硬化程度之间的关系的信息很少。方法对204名2~39岁的年轻人进行尸检，他们死于各种原因，主要是创伤。这些人中有93人的生前危险因素的数据是可用的，他们是本研究的重点。我们将危险因素与主动脉和冠状动脉的动脉粥样硬化程度相关联。结果随着年龄的增长，主动脉和冠状动脉的脂肪条纹和纤维斑块的程度增加。冠状动脉内脂肪条纹与纤维斑块的相关性更强(r=0.60，P
Background In adults, cardiovascular risk factors reinforce each other in their effect on cardiovascular events. However, information is scant on the relation of multiple risk factors to the extent of asymptomatic atherosclerosis in young people.Methods We performed autopsies on 204 young persons 2 to 39 years of age, who had died from various causes, principally trauma. Data on antemortem risk factors were available for 93 of these persons, who were the focus of this study. We correlated risk factors with the extent of atherosclerosis in the aorta and coronary arteries.Results The extent of fatty streaks and fibrous plaques in the aorta and coronary arteries increased with age. The association between fatty streaks and fibrous plaques was much stronger in the coronary arteries (r=0.60, P