Neuroradiographic findings in the newborn period and long-term outcome in children with symptomatic congenital cytomegalovirus infection
Neuroradiographic findings in the newborn period and long-term outcome in children with symptomatic congenital cytomegalovirus infection
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DOI：
10.1542/peds.99.3.409
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发表时间：
1997-03-01
期刊：
影响因子：
8
通讯作者：
Pass, RF
中科院分区：
文献类型：
--
作者：
Boppana, SB;Fowler, KB;Pass, RF
Objective.确定新生儿头颅CT扫描异常是否预示有症状的先天性巨细胞病毒（CMV）感染儿童的不良神经发育结局，并检查出生时临床表现与影像学异常之间的相关性。分析了56例有症状的先天性CMV感染儿童的数据，这些儿童在新生儿时接受了头颅CT扫描，并参加了长期随访研究。比较影像学检查正常和异常儿童组的后遗症发生率。同时分析CT扫描结果与新生儿其他检查结果的关系。在70%的受试者中观察到异常CT扫描;脑内钙化是最常见的发现。大多数新生儿CT扫描异常的儿童（90%）至少有一种后遗症，而正常研究的儿童只有29%。只有一个CT扫描正常的孩子有智商
Objective. To determine whether newborn cranial computed tomographic (CT) scan abnormalities predict an adverse neurodevelopmental outcome in children with symptomatic congenital cytomegalovirus (CMV) infection and to examine the association between clinical findings at birth and imaging abnormalities.Methods. The data from 56 children with symptomatic congenital CMV infection who underwent cranial CT scans as newborns and were enrolled in a long-term follow-up study were analyzed. The incidence of sequelae was compared between the groups of children with normal and abnormal imaging studies. The relationship between CT scan results and other newborn findings was also examined.Results. Abnormal CT scans were noted in 70% of subjects; intracerebral calcification was the most frequent finding. Most of the children with an abnormal newborn CT scan (90%) developed at least one sequela, compared with 29% of those with a normal study. Only 1 child with a normal CT scan had an IQ