Optimal Monitoring of Prostate-Specific Antigen Detects Prostate Cancer at the Localized Stage after Photoselective Vaporization for Benign Prostatic Hyperplasia.
Optimal Monitoring of Prostate-Specific Antigen Detects Prostate Cancer at the Localized Stage after Photoselective Vaporization for Benign Prostatic Hyperplasia.
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DOI：
10.1159/000489433
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发表时间：
2019-05-10
期刊：
影响因子：
1.6
通讯作者：
Kuromatsu, Isao
中科院分区：
文献类型：
--
作者：
Furusawa, Jun;Yamada, Yasushi;Kuromatsu, Isao
简介：前列腺光选择性汽化 (PVP) 不提供用于病理分析的前列腺组织。在这里，我们通过测量前列腺特异性抗原（PSA）水平并评估 PVP 后的临床病理特征来进行前列腺癌的早期监测。 材料和方法：对接受 PVP 并随访超过 12 个月的患者 (n = 800) 进行回顾性分析。 PVP 后，在第 3 个月和 12 个月以及此后每年测量 PSA 水平。当 PSA 水平持续升高时进行前列腺活检。我们评估了诊断为前列腺癌的患者的特征。结果：平均随访期为 49 个月。 PVP 后，54 名患者接受了活检，其中 23 名患者被诊断患有前列腺癌。总体而言，分别有 10、10 和 3 名患者处于临床 T1c、T2a 和 T2b 期疾病，并且没有 T2c 期或更高期疾病的病例。结论：我们发现，根据 PVP 前后的最佳 PSA 监测方案，可以在局部分期诊断前列腺癌。
INTRODUCTION: Photoselective vaporization of the prostate (PVP) does not provide prostate tissue for pathologic analysis. Here, we carried out early monitoring for prostate cancer by measuring prostate-specific antigen (PSA) levels and assessing clinicopathological features after PVP.MATERIALS AND METHODS: Patients (n = 800) who underwent PVP and were followed-up for more than 12 months were analyzed retrospectively. After PVP, PSA levels were measured at 3 and 12 months and each year thereafter. Prostate biopsies were performed when PSA levels increased continuously. We assessed the characteristics of patients diagnosed with prostate cancer.RESULTS: The mean follow-up period was 49 months. After PVP, 54 patients underwent biopsies, and 23 patients were diagnosed with prostate cancer. Overall, 10, 10, and 3 patients had clinical stage T1c, T2a, and T2b disease, respectively, and there were no cases of stage T2c disease or greater.CONCLUSIONS: We found that it was possible to diagnose prostate cancer at a localized stage under our optimal PSA monitoring schedule before and after PVP.