Isolation and anticomplement activity of compounds from Dendropanax morbifera
Isolation and anticomplement activity of compounds from Dendropanax morbifera
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DOI：
10.1016/j.jep.2003.11.002
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发表时间：
2004-02-01
影响因子：
5.4
通讯作者：
Lee, HK
中科院分区：
文献类型：
--
作者：
Park, BY;Min, BS;Lee, HK
在韩国，石斛被用于治疗偏头痛和痛经等多种疾病。利用常规色谱技术从该植物的叶片中分离到一个新的聚乙炔(1)和6个已知化合物（2-7）。新聚乙炔(1)的结构为(9Z, 16S)-16-羟基-9,17-十八烯二烯-12,14-二甲酸，采用二维核磁共振等波谱方法，其中包括用改良Mosher酯法测定手性。体外研究了化合物1-7对补体系统经典途径的抗补体活性。其中，化合物1表现出显著的抗补体活性，50%抑制浓度（IC50）值为56.98 muM，而化合物2-7无活性。2003爱思唯尔爱尔兰有限公司版权所有。
Dendropanax morbifera Leveille (Araliaceae) is used in Korea for a variety of disease, such as migraine headache and dysmenorrheal. A new polyacetylene (1) and six known compounds (2-7) were isolated from the leaves of this plant by conventional chromatographic techniques. The structure of the new polyacetylene (1) was determined as (9Z, 16S)-16-hydroxy-9,17-octadecadiene-12,14-diynoic acid by spectroscopic means including 2D NMR, which comprised the determination of a chiral by modified Mosher's ester method. Compounds 1-7 were investigated in vitro for their anticomplement activity against the classical pathway of the complement system. Of these, compound I showed significant anticomplement activity with 50% inhibitory concentration (IC50) value of 56.98 muM, whereas compounds 2-7 were inactive. (C) 2003 Elsevier Ireland Ltd. All rights reserved.