Thirty-year trends in clinicopathologic characteristics and prognosis after gastrectomy for gastric cancer: A single institution in Northern China
Thirty-year trends in clinicopathologic characteristics and prognosis after gastrectomy for gastric cancer: A single institution in Northern China
复制标题
胃癌胃切除术后临床病理特征和预后三十年趋势：中国北方单一机构
DOI：
10.7150/jca.36927
复制
发表时间：
2020-01-01
影响因子：
3.9
通讯作者：
Xu, Hui-mian
中科院分区：
文献类型：
--
作者：
Tan, Yu-en;Wang, Peng-liang;Xu, Hui-mian
背景：我们综合了30年来中国北方胃癌患者的临床病理特征和术后预后的变化趋势。方法：回顾性分析1981年1月至2010年12月在中国医科大学第一附属医院行胃癌切除术的患者及完整的随访资料。我们把病人分成三个连续的阶段。结果：本研究共纳入3520例患者。下部肿瘤占比由58.8%上升至66.9%，上部肿瘤占比由21.3%下降至13.4%。bbb50 cm的肿瘤比例下降（从58.6%下降到41.1%），但低分化胃癌的上升趋势明显（从60.1%上升到75.7%）。在研究期间，早期胃癌的比例从10.0%上升到15.5%，TNM IV期癌症的比例从38.6%下降到28.1%。手术治疗中，近期根治率提高至92.1%，平均淋巴结清扫数增加。5年生存率由36.5%逐渐提高到48.5% (p
Background: We integrated changes in the trends in clinicopathologic characteristics and postoperative prognosis in patients with gastric cancer Northern China over a 30-year period.Methods: A retrospective analysis of patients undergoing gastric cancer resection and complete follow-up information from January 1981 to December 2010 in the first affiliated Hospital of China Medical University was carried out. We divided the patients into three consecutive periods.Results: A total of 3,520 patients were included in this study. The proportion of lower tumors increased (from 58.8 to 66.9%), while that of upper tumors decreased (from 21.3 to 13.4%). The proportion of tumors > 5cm decreased (from 58.6 to 41.1 %), but the increasing trend of poorly differentiated gastric cancer was obvious (from 60.1 to 75.7%). The percentage of early gastric cancer increased from 10.0 to 15.5 during the study periods, and that of TNM stage IV cancer decreased from 38.6 to 28.1. In surgery treatment, the rate of radical resection increased to 92.1% in recent period, and the average number of retrieved lymph nodes increased. The 5-year survival rate gradually increased from 36.5% to 48.5% (p